用鼠标模拟人类疾病：系统性红斑狼疮中的认知障碍。
Using the Mouse to Model Human Diseases: Cognitive Impairment in Systemic Lupus Erythematosus.
机构信息
From the Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
L. El Khoury, MD, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health; A. Zarfeshani, PhD, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health; B. Diamond, MD, Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health.
出版信息
J Rheumatol. 2020 Jul 1;47(7):1145-1149. doi: 10.3899/jrheum.200410. Epub 2020 Apr 15.
In this 2020 Dunlop-Dottridge Lecture, the authors discuss cognitive impairment (CI), one of the most prevalent neuropsychiatric syndromes in systemic lupus erythematosus (SLE). Patients often report CI as the most bothersome disease-related manifestation, with a great effect on their quality of life. Nevertheless, studies focusing on CI remain scarce and no effective targeted therapy has been identified. We herein present murine models of CI in SLE with insights into the pathogenesis of this condition as well as the role of the renin angiotensin system in microglial activation. We will discuss the role of neuroimaging as a useful objective assessment tool, describing our experience in previous and ongoing clinical trials of CI in patients with SLE.
在本次 2020 年邓洛普-多特里奇讲座中，作者们讨论了认知障碍（CI），这是系统性红斑狼疮（SLE）中最常见的神经精神综合征之一。患者常报告 CI 是最令人困扰的与疾病相关的表现，对其生活质量有重大影响。然而，针对 CI 的研究仍然很少，也没有确定有效的靶向治疗方法。我们在此介绍了 SLE 中与 CI 相关的小鼠模型，深入了解了这种疾病的发病机制以及肾素-血管紧张素系统在小胶质细胞激活中的作用。我们将讨论神经影像学作为一种有用的客观评估工具的作用，描述我们在 SLE 患者 CI 的既往和正在进行的临床试验中的经验。
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