Sun Xiangyu, Wang Mozhi, Wang Mengshen, Yu Xueting, Guo Jingyi, Sun Tie, Li Xinyan, Yao Litong, Dong Haoran, Xu Yingying
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China.
Front Oncol. 2020 Mar 31;10:428. doi: 10.3389/fonc.2020.00428. eCollection 2020.
Metabolic reprogramming is an emerging hallmark of cancer cells, in which cancer cells exhibit distinct metabolic phenotypes to fuel their proliferation and progression. The significant advancements made in the area of metabolic reprogramming make possible new strategies for overcoming malignant cancer, including triple-negative breast cancer. Triple-negative breast cancer (TNBC) is associated with high histologic grade, aggressive phenotype, and poor prognosis. Even though triple-negative breast cancer patients benefit from standard chemotherapy, they still face high recurrence rates and are more likely to develop resistance to chemotherapeutic drugs. Therefore, there is an urgent need to explore vulnerabilities of triple-negative breast cancer and develop novel therapeutic drugs to improve clinical outcomes for triple-negative breast cancer patients. Metabolic reprogramming may provide promising therapeutic targets for the treatment of triple-negative breast cancer. In this paper, we primarily discuss how triple-negative breast cancer cells reprogram their metabolic phenotype and that of stromal cells in the microenvironment to survive under nutrient-poor conditions. Considering that metastasis and chemoresistance are the main contributors to mortality in triple-negative breast cancer patients, we also focus on the role of metabolic adaption in mediating metastasis and chemoresistance of triple-negative breast cancer tumors.
代谢重编程是癌细胞新出现的一个特征，其中癌细胞表现出独特的代谢表型以促进其增殖和进展。代谢重编程领域取得的重大进展为攻克恶性肿瘤（包括三阴性乳腺癌）带来了新策略。三阴性乳腺癌（TNBC）与高组织学分级、侵袭性表型和不良预后相关。尽管三阴性乳腺癌患者从标准化疗中获益，但他们仍面临高复发率，且更有可能对化疗药物产生耐药性。因此，迫切需要探索三阴性乳腺癌的脆弱性并开发新型治疗药物，以改善三阴性乳腺癌患者的临床结局。代谢重编程可能为三阴性乳腺癌的治疗提供有前景的治疗靶点。在本文中，我们主要讨论三阴性乳腺癌细胞如何重编程其代谢表型以及微环境中基质细胞的代谢表型，以便在营养匮乏的条件下存活。鉴于转移和化疗耐药是三阴性乳腺癌患者死亡的主要原因，我们还关注代谢适应在介导三阴性乳腺癌肿瘤转移和化疗耐药中的作用。
