Institute of Biology, University of Szczecin, Szczecin, Poland.
Students' Scientific Immunology Circle at the University of Szczecin, Szczecin, Poland.
Arch Immunol Ther Exp (Warsz). 2020 Apr 15;68(2):13. doi: 10.1007/s00005-020-00578-2.
Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being a worldwide risk to health of many people. In this review, we highlight the role of immune cells and its influence in the development of autoimmunity in Langerhans islets. Moreover, we discuss the impact of the immunological factors on future understanding possible recurrence of autoimmunity on 3D-bioprinted bionic pancreas.
免疫系统和胰腺之间的相互作用对于理解β细胞损伤如何以及为何导致胰腺功能障碍至关重要。胰岛在维持器官、组织和细胞内葡萄糖稳态方面起着至关重要的作用。针对胰岛，主要是β细胞的自身免疫攻击导致 1 型糖尿病——这是世界上最常见的自身免疫性疾病之一，也是全球许多人健康的一个风险因素。在这篇综述中，我们强调了免疫细胞的作用及其对朗格汉斯胰岛自身免疫发生的影响。此外，我们还讨论了免疫因素对未来理解 3D 生物打印仿生胰腺自身免疫复发可能性的影响。
