Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Spedding Research Solutions SAS, Le Vésinet, France.
Immunology. 2020 May;160(1):1-2. doi: 10.1111/imm.13201.
In the era of big data, the establishment of a free database, containing all the immune drug targets and associated cell types, is of great value. To this aim, the Guide to Immunopharmacology has been created in a joint effort between the International Union of Basic and Clinical Pharmacology (IUPHAR) and the International Union of Immunological Societies (IUIS). Here we highlight the structure and content of the database, which includes up-to-date quantitative information on the fundamental science underlying each immune target. A set of practical examples and tools for data mining are summarized to support immune research into drug discovery and therapeutics.
在大数据时代,建立一个包含所有免疫药物靶点和相关细胞类型的免费数据库具有重要价值。为此,国际药理学联合会(IUPHAR)和国际免疫学联盟(IUIS)共同创建了免疫药理学指南。在这里,我们重点介绍了数据库的结构和内容,其中包括每个免疫靶点基础科学的最新定量信息。总结了一组用于数据挖掘的实用示例和工具,以支持药物发现和治疗学的免疫研究。