Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
Medicines for Malaria Venture, Post Box 1826, 1215 Geneva 15, Switzerland.
Nucleic Acids Res. 2020 Jan 8;48(D1):D1006-D1021. doi: 10.1093/nar/gkz951.
The IUPHAR/BPS Guide to PHARMACOLOGY (www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe significant updates made over the seven releases during the last two years. The database is notably enhanced through the continued linking of relevant pharmacology with key immunological data types as part of the IUPHAR Guide to IMMUNOPHARMACOLOGY (www.guidetoimmunopharmacology.org) and by a major new extension, the IUPHAR/MMV Guide to Malaria PHARMACOLOGY (www.guidetomalariapharmacology.org). The latter has been constructed in partnership with the Medicines for Malaria Venture, an organization dedicated to identifying, developing and delivering new antimalarial therapies that are both effective and affordable. This is in response to the global challenge of over 200 million cases of malaria and 400 000 deaths worldwide, with the majority in the WHO Africa Region. It provides new pharmacological content, including molecular targets in the malaria parasite, interaction data for ligands with antimalarial activity, and establishes curation of data from screening assays, used routinely in antimalarial drug discovery, against the whole organism. A dedicated portal has been developed to provide quick and focused access to these new data.
国际药理学联合会/英国药理学学会药物受体数据库（www.guidetopharmacology.org）是一个开放获取的、专家编辑的配体与其靶标之间分子相互作用数据库。我们描述了过去两年中七个版本的显著更新。通过将相关药理学与关键免疫数据类型持续链接，作为国际药理学联合会免疫药理学指南（www.guidetoimmunopharmacology.org）的一部分，以及通过一个重大的新扩展，即国际药理学联合会/MMV 疟疾药理学指南（www.guidetomalariapharmacology.org），该数据库得到了显著增强。后者是与疟疾药物开发伙伴关系组织（ Medicines for Malaria Venture ）合作构建的，该组织致力于发现、开发和提供既有效又负担得起的新抗疟疗法。这是为了应对全球超过 2 亿例疟疾病例和全球 40 万人死亡的全球挑战，其中大多数在世界卫生组织非洲区域。它提供了新的药理学内容，包括疟原虫中的分子靶标、具有抗疟活性的配体的相互作用数据，并建立了对整个生物体进行筛选测定的药物发现中常用的抗疟药物数据的整理。还开发了一个专门的门户，以快速、集中地访问这些新数据。
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