Sharman Joanna L, Harding Simon D, Southan Christopher, Faccenda Elena, Pawson Adam J, Davies Jamie A
Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Curr Protoc Bioinformatics. 2018 Mar;61(1):1.34.1-1.34.46. doi: 10.1002/cpbi.46.
The IUPHAR/BPS Guide to PHARMACOLOGY is an expert-curated, open-access database of information on drug targets and the substances that act on them. This unit describes the procedures for searching and downloading ligand-target binding data and for finding detailed annotations and the most relevant literature. The database includes concise overviews of the properties of 1,700 data-supported human drug targets and related proteins, divided into families, and 9,000 small molecule and peptide experimental ligands and approved drugs that bind to those targets. More detailed descriptions of pharmacology, function, and pathophysiology are provided for a subset of important targets. The information is reviewed regularly by expert subcommittees of the IUPHAR Committee on Receptor Nomenclature and Drug Classification. A new immunopharmacology portal has recently been added, drawing together data on immunological targets, ligands, cell types, processes and diseases. The data are available for download and can be accessed computationally via Web services. © 2018 by John Wiley & Sons, Inc.
《IUPHAR/BPS 药理学指南》是一个由专家精心策划的开放获取数据库，提供有关药物靶点及作用于这些靶点的物质的信息。本单元介绍了搜索和下载配体 - 靶点结合数据以及查找详细注释和最相关文献的程序。该数据库包括对 1700 个有数据支持的人类药物靶点及相关蛋白质特性的简要概述，这些靶点和蛋白质按家族分类，还包括 9000 种与这些靶点结合的小分子和肽类实验性配体及获批药物。对于一部分重要靶点，还提供了更详细的药理学、功能和病理生理学描述。这些信息由 IUPHAR 受体命名与药物分类委员会的专家小组定期审查。最近新增了一个免疫药理学门户，汇集了有关免疫靶点、配体、细胞类型、过程和疾病的数据。这些数据可供下载，也可通过网络服务进行计算访问。© 2018 约翰威立国际出版公司
