Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital of Messina, Italy.
J Surg Oncol. 2020 Aug;122(2):170-175. doi: 10.1002/jso.25927. Epub 2020 Apr 15.
Among orbital tumors, metastatic lesions have a prevalence of 1% to 13%; on the other hand, breast cancer is the most common malignancy causing orbital metastases. The aim of this study is to present our experience dealing with orbital metastases caused by breast cancer, to assess characteristics and clinic-pathological data of patients suffering from this rare occurrence and to find indexes related with their prognosis and survival.
Records of 28 patients diagnosed with orbital metastases from breast cancer at the Department of Ophthalmology, Humanitas Clinical and Research Centre of Milano over a 27-year period (1992-2018) were retrieved and analyzed.
Mean patients' age at breast cancer diagnosis was 56.29 ± 14.63 years. Mean time interval between breast cancer diagnosis and orbital metastasis occurrence was 5 ± 4.17 years. All lesions were estrogen receptor-positive; 79% of patients harbored progesterone receptor-positive lesions. Interestingly, the majority of deceased patients presented orbital lesions with MIB-1 index >50% (P = .0265) and had concomitant lung metastases (P = .0452).
The occurrence of orbital metastasis from breast cancer represents a challenging finding. Patients' clinical picture can include exophthalmos, edema, tumefaction, proptosis and/or diplopia. Significant symptomatic improvement can be achieved through surgery and other adjuvant treatments, such as radiation therapy and chemotherapy.
在眼眶肿瘤中，转移性病变的患病率为 1%至 13%；另一方面，乳腺癌是导致眼眶转移的最常见恶性肿瘤。本研究旨在介绍我们在处理乳腺癌引起的眼眶转移方面的经验，评估患有这种罕见疾病的患者的特征和临床病理数据，并找到与预后和生存相关的指标。
检索了 2018 年在米兰 Humanitas 临床与研究中心眼科诊断为乳腺癌眼眶转移的 28 例患者的记录，并进行了分析。
乳腺癌诊断时患者的平均年龄为 56.29±14.63 岁。乳腺癌诊断与眼眶转移发生之间的平均时间间隔为 5±4.17 年。所有病变均为雌激素受体阳性；79%的患者孕激素受体阳性病变。有趣的是，大多数死亡患者的眼眶病变 MIB-1 指数>50%（P=0.0265），且同时伴有肺转移（P=0.0452）。
乳腺癌眼眶转移的发生是一个具有挑战性的发现。患者的临床表现可能包括眼球突出、水肿、肿胀、眼球突出和/或复视。通过手术和其他辅助治疗，如放射治疗和化疗，可以显著改善症状。
