Chemical Engineering Department, School of Industrial Engineering - Módulo Tecnológico Industrial (MTI), University of Vigo, Vigo, Spain.
Chemical Engineering Department, Barcelona East School of Engineering (EEBE), Polytechnic University of Catalonia (UPC)-Barcelona TECH, Barcelona, Spain.
J Dermatolog Treat. 2022 Feb;33(1):393-400. doi: 10.1080/09546634.2020.1757016. Epub 2020 Apr 23.
This is a novel work that includes the use of a biosurfactant extract obtained from corn milling industry (named BS-CSW), with antimicrobial activity, as ingredient in formulations to treat acne vulgaris.
With this purpose, it was established an incomplete experimental design with 3 independent variables, based on the concentration of non-nano zinc oxide (ZnO) (0-2%), BS-CSW (0-5%) and salicylic acid (0-2%).
This design allowed to obtain a theoretical model that calculates the inhibitory effect on (also named ) for any formulation carried with the ingredients appointed before. It was observed a clear synergetic effect on the inhibition of between ZnO and BS-CSW, in absence of salicylic acid. This fact allowed to reduce the concentration of ZnO, giving more ecofriendly and biocompatible formulations.
It was observed that the biosurfactant extract, in formulations with intermediate concentration of ZnO (1%), possess an inhibitory effect on considerably higher than ZnO alone and similar to ZnO (1%) with salicylic acid (1%). This fact demonstrates the enormous potential of this bioactive extract in antiacne formulations.
这是一项新颖的工作，其中包含使用从玉米加工行业获得的生物表面活性剂提取物（命名为 BS-CSW），该提取物具有抗菌活性，作为治疗寻常痤疮配方的成分。
为此，我们建立了一个具有 3 个独立变量的不完全实验设计，这 3 个独立变量基于非纳米氧化锌（ZnO）（0-2%）、BS-CSW（0-5%）和水杨酸（0-2%）的浓度。
该设计允许获得一个理论模型，该模型可以计算出任何指定成分的配方对（也称为 ）的抑制效果。我们观察到 ZnO 和 BS-CSW 之间对 的抑制作用存在明显的协同作用，而在没有水杨酸的情况下也是如此。这一事实允许降低 ZnO 的浓度，从而提供更环保和更具生物相容性的配方。
我们观察到，在 ZnO 浓度中等（1%）的配方中，生物表面活性剂提取物对 的抑制作用明显高于单独的 ZnO，并且与含有 1%水杨酸的 ZnO 相似。这一事实证明了这种生物活性提取物在抗痤疮配方中的巨大潜力。
