桑辛素通过 PI3K-AKT 信号通路抑制人骨肉瘤。
Morusin Inhibits Human Osteosarcoma via the PI3K-AKT Signaling Pathway.
机构信息
Departments of Trauma Orthopedics, Ningbo No. 6 Hospital, Ningbo 315000, Zhejiang, China.
Departments of Neurology, The Affiliated Hospital of the Medical School of Ningbo University, 315000, Zhejiang, China.
出版信息
Curr Pharm Biotechnol. 2020;21(13):1402-1409. doi: 10.2174/1389201021666200416093457.
OBJECTIVE
Osteosarcoma is considered as one of the most common types of bone tumors, which occurs among adolescents and children.
METHODS
Current therapy strategies still have limited effectiveness therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear.
RESULTS
In this study, we determined that morusin significantly suppresses the proliferation and promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin. The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway.
CONCLUSION
In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy.
目的
骨肉瘤被认为是最常见的骨肿瘤类型之一，主要发生在青少年和儿童中。
方法
目前的治疗策略仍然效果有限，因此迫切需要开发新的治疗方法。桑辛素是从桑（桑科）中分离得到的一种化合物。许多研究报告称，它对几种肿瘤类型具有抗肿瘤作用。然而，其在骨肉瘤中的作用尚不清楚。
结果
在这项研究中，我们确定桑辛素可显著抑制骨肉瘤细胞的增殖并促进其凋亡。此外，桑辛素处理后骨肉瘤的迁移和侵袭减少。其深层机制被确定为抑制 PI3K/AKT 信号通路。
结论
总之，我们的研究表明桑辛素可能成为骨肉瘤治疗的候选药物。
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