姜黄素，黑种草中的一种活性化合物：在癌症预防和治疗中的作用。
Thymoquinone, an Active Compound of Nigella sativa: Role in Prevention and Treatment of Cancer.
机构信息
Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah, Saudi Arabia.
出版信息
Curr Pharm Biotechnol. 2020;21(11):1028-1041. doi: 10.2174/1389201021666200416092743.
BACKGROUND
Cancer is the leading cause of death worldwide and the current mode of cancer treatment causes side effects on normal cells and are still the key challenges in its' treatment. However, natural products or active compounds of medicinal plants have shown to be safe, affordable, and effective in diseases cure.
METHODS
In this context, scientific studies evidence the health-promoting effects of natural products, which work through its anti-oxidant, anti-inflammatory, and anti-cancer activity. Thymoquinone (TM), a predominant active compound of Nigella sativa, has confirmed anti-neoplastic activity through its ability to regulate various genetic pathways. In addition, thymoquinone has established anti-cancerous effects through killing of various cancerous cells,and inhibiting the initiation, migration, invasion, and progression of the cancer. The anti-cancer effects of TM are chiefly mediated via regulating various cell signaling pathways such as VEGF, bcl2/bax ratio, p53, NF-kB, and oncogenes.
RESULTS
The anti-cancer drugs have limitations in efficacy and also causes adverse side effects on normal cells. The combination of anti-cancer drugs and thymoquinone improves the efficacy of drugs which is evident by decrease resistance to drugs and regulation of various cell signaling pathways. Moreover, combination of anti-cancer drugs as well as thymoquinone shows synergistic effect on killing of cancer cells and cells viability. Thus, TM, in combination with anti-cancer drugs, can be a good strategy in the management of various types of cancer.
CONCLUSION
In this review article, we deliver an outline of thymoquinone role in cancer inhibition and prevention of cancer-based on in vivo and in vitro studies. Further studies on thymoquinone based on clinical trials are highly required to explore the benefits of thymoquinone in cancer management.
背景
癌症是全球主要的死亡原因，目前的癌症治疗模式会对正常细胞产生副作用，仍是癌症治疗的关键挑战。然而，药用植物的天然产物或活性化合物已被证明在疾病治疗中安全、经济实惠且有效。
方法
在这种情况下，科学研究证明了天然产物具有促进健康的作用，其通过抗氧化、抗炎和抗癌活性发挥作用。百里醌（TM）是黑种草的主要活性化合物，通过调节各种遗传途径，证实具有抗肿瘤活性。此外，通过杀死各种癌细胞并抑制癌症的起始、迁移、浸润和进展，已确定百里醌具有抗癌作用。TM 的抗癌作用主要通过调节各种细胞信号通路介导，如 VEGF、bcl2/bax 比值、p53、NF-kB 和癌基因。
结果
抗癌药物在疗效上存在局限性，而且对正常细胞也会产生不良的副作用。抗癌药物与百里醌联合使用可提高药物疗效，这表现在降低耐药性和调节各种细胞信号通路方面。此外，抗癌药物与百里醌联合使用对杀伤癌细胞和细胞活力具有协同作用。因此，TM 与抗癌药物联合使用可能是治疗各种类型癌症的一种好策略。
结论
在这篇综述文章中，我们根据体内和体外研究，概述了百里醌在癌症抑制和预防中的作用。需要进行更多基于百里醌的临床试验研究，以探索百里醌在癌症管理中的益处。
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