Department of Medical Biology, Ankara Yildirim Beyazit University, Ankara, Turkey.
Department of Medical Biology, Ankara University Ankara, Turkey.
J Enzyme Inhib Med Chem. 2024 Dec;39(1):2339901. doi: 10.1080/14756366.2024.2339901. Epub 2024 Jun 12.
The spices and aromatic herbs were used not only in cooking to add flavour and smell to dishes but also for medicinal use. Nigella sativa, also called black cumin, is one of the species that contains an important bioactive component, thymoquinone (TQ), which has antioxidant, anti-inflammatory, antimicrobial, and antidiabetic effects. Curcuma longa, which also includes curcumin, has numerous anti-cancer properties. However, the bioavailability of curcumin is lower than that of its analogs. An analog of curcumin (EF-24), which has better bioavailability than curcumin, is capable of exerting a high anti-cancer effect. In our study, we determined the effects of PON1 enzyme activity on the proliferation and aggressiveness of glioblastoma cancer treated with TQ and EF-24 from lysates of the glioblastoma cell line U87MG. The results were determined as increased PON1 activity after treatment with TQ and EF-24 in the U87MG cell line ( < 0.0001).
香料和香草不仅用于烹饪，为菜肴增添风味和香气，也用于药用。黑孜然，也称为黑孜然，是一种含有重要生物活性成分的物种之一，即百里醌（TQ），具有抗氧化、抗炎、抗菌和抗糖尿病作用。姜黄，其中也包括姜黄素，具有许多抗癌特性。然而，姜黄素的生物利用度低于其类似物。姜黄素的类似物（EF-24）具有比姜黄素更好的生物利用度，能够发挥高抗癌作用。在我们的研究中，我们确定了 PON1 酶活性对用 TQ 和 EF-24 治疗的神经胶质瘤细胞系 U87MG 中增殖和侵袭性的影响。结果表明，在用 TQ 和 EF-24 处理后，U87MG 细胞系中的 PON1 活性增加（<0.0001）。
