Jensen E J, Rungby J, Hansen J C, Schmidt E, Pedersen B, Dahl R
Department of Respiratory Medicine, University Hospital, Aarhus, Denmark.
Hum Toxicol. 1988 Nov;7(6):535-40. doi: 10.1177/096032718800700603.
Silver acetate chewing gum was used for 12 weeks as a smoking deterrent in 21 adults. The effect of silver on serum concentrations, its accumulation in the skin and the risk of developing clinically evident argyria were investigated. Serum concentrations of silver clearly rose after chewing gum use had started, and concentrations quickly returned to normal after use had ceased. In most cases the number of silver granules in skin biopsies, observed by autometallography, increased after the gum had been used for 12 weeks. No one developed clinical signs of argyria. Silver acetate containing remedies can be used as an aid to stop smoking, but the consumption must be monitored to avoid accumulation of larger amounts of silver in the body.
21名成年人使用醋酸银口香糖作为戒烟剂，为期12周。研究了银对血清浓度的影响、其在皮肤中的蓄积以及发生临床明显银质沉着病的风险。开始咀嚼口香糖后，血清银浓度明显升高，停止使用后浓度迅速恢复正常。在大多数情况下，通过自动金相显微镜观察，使用口香糖12周后皮肤活检中的银颗粒数量增加。没有人出现银质沉着病的临床症状。含醋酸银的药物可作为戒烟辅助剂，但必须监测其摄入量，以避免体内银大量蓄积。
