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Involvement of thiols in the induction of inward current induced by silver in frog skeletal muscle membrane.

作者信息

Aoki T, Nihonyanagi K, Oba T

机构信息

Department of Food and Nutrition Science, Gifu City Women's College, Japan.

出版信息

Experientia. 1993 Sep 15;49(9):792-4. doi: 10.1007/BF01923550.

DOI:10.1007/BF01923550
PMID:8405303
Abstract

Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thus, silver activates the Ca2+ channel by acting on SH groups in a Ca2+ channel protein.

摘要

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本文引用的文献

1
Experimental argyrosis; hypertrophy of the left ventricle of the heart in rats ingesting silver salts.实验性银质沉着病；摄入银盐的大鼠心脏左心室肥大。
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Muscle contraction and inward current induced by silver and effect of Ca2+ channel blockers.
Am J Physiol. 1993 Apr;264(4 Pt 1):C852-6. doi: 10.1152/ajpcell.1993.264.4.C852.
4
Existence of a sodium-induced calcium release mechanism of frog skeletal muscle fibres.蛙骨骼肌纤维钠诱导钙释放机制的存在。
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Heavy metals induce rapid calcium release from sarcoplasmic reticulum vesicles isolated from skeletal muscle.重金属可诱导从骨骼肌分离出的肌浆网囊泡快速释放钙。
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1526-30. doi: 10.1073/pnas.80.6.1526.
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Calcium currents in a fast-twitch skeletal muscle of the rat.大鼠快肌骨骼肌中的钙电流。
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7
A non-selective cation conductance in frog muscle membrane blocked by micromolar external calcium ions.蛙肌膜中的一种非选择性阳离子电导被微摩尔浓度的细胞外钙离子所阻断。
J Physiol. 1984 Aug;353:565-83. doi: 10.1113/jphysiol.1984.sp015351.
8
Silver ion-induced tension development and membrane depolarization in frog skeletal muscle fibres.银离子诱导青蛙骨骼肌纤维的张力发展和膜去极化。
Pflugers Arch. 1985 Dec;405(4):354-9. doi: 10.1007/BF00595688.
9
Effects of extracellular calcium and calcium channel blocker on silver-induced contractures in frog skeletal muscle fibers.细胞外钙和钙通道阻滞剂对青蛙骨骼肌纤维银诱导挛缩的影响。
Jpn J Physiol. 1987;37(1):125-35. doi: 10.2170/jjphysiol.37.125.
10
Serum concentrations and accumulation of silver in skin during three months treatment with an anti-smoking chewing gum containing silver acetate.在使用含醋酸银的戒烟口香糖进行三个月治疗期间，血清中银的浓度及皮肤中银的蓄积情况。
Hum Toxicol. 1988 Nov;7(6):535-40. doi: 10.1177/096032718800700603.