Johnson J P, Stade B G, Hupke U, Holzmann B, Riethmüller G
Institute of Immunology, Munich, Federal Republic of Germany.
Immunobiology. 1988 Dec;178(3):275-84. doi: 10.1016/S0171-2985(88)80071-8.
The 89kd cell surface glycoprotein, P3.58, is expressed on human malignant melanomas in situ where it is associated with an increased risk of metastatic disease. Monoclonal antibodies detecting denatured P3.58 were produced and used to isolate a P3.58 encoding cDNA clone from a human melanoma lambda expression library. Sequencing of the cDNA revealed that the P3.58 antigen is identical to the leukocyte intercellular adhesion molecule 1 (ICAM-1).
89kd细胞表面糖蛋白P3.58在原位人类恶性黑色素瘤中表达，它与转移性疾病风险增加有关。制备了检测变性P3.58的单克隆抗体，并用于从人黑色素瘤λ表达文库中分离编码P3.58的cDNA克隆。对该cDNA进行测序后发现，P3.58抗原与白细胞细胞间黏附分子1（ICAM-1）相同。
