You Yawen, Cao Fangfang, Zhao Yajie, Deng Qingqing, Sang Yanjuan, Li Yang, Dong Kai, Ren Jinsong, Qu Xiaogang
State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China.
University of Science and Technology of China, Hefei, Anhui 230029, P.R. China.
ACS Nano. 2020 Apr 28;14(4):4178-4187. doi: 10.1021/acsnano.9b08949. Epub 2020 Apr 20.
Owing to better stability and biosafety, heterogeneous Cu nanoparticles (CuNPs) have been put forward as a promising candidate to complete the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. However, the inherent poor activity of Cu(0) deterred its wide bioapplication. Herein, we employed near-infrared (NIR) light to dual-promote the CuAAC reaction of a biocompatible heterogeneous copper nanocatalyst through photodynamic and photothermal effects and . Specifically, the photodynamic activity could promote the conversion of Cu(0) to Cu(I) to accelerate the catalytic process of CuAAC. The high photothermal conversion efficiency (η = 50.6%) could increase the local temperature, further promoting the whole reaction. Then, a drastically increased reaction rate in a living system ranging from cells to nematodes was achieved in our system. Meanwhile, the better antitumor efficacy has determined with tumor therapy experiments.
由于具有更好的稳定性和生物安全性，异质铜纳米颗粒（CuNPs）已被提出作为完成铜（I）催化的叠氮化物-炔烃环加成反应（CuAAC）的有前途的候选物。然而，铜（0）固有的低活性阻碍了其广泛的生物应用。在此，我们利用近红外（NIR）光通过光动力和光热效应双重促进生物相容性异质铜纳米催化剂的CuAAC反应。具体而言，光动力活性可促进铜（0）向铜（I）的转化，以加速CuAAC的催化过程。高光热转换效率（η = 50.6%）可提高局部温度，进一步促进整个反应。然后，在我们的系统中，在从细胞到线虫的活体系统中实现了反应速率的大幅提高。同时，通过肿瘤治疗实验确定了更好的抗肿瘤疗效。
