Microbial Evolutionary Genomics, Institut Pasteur, CNRS, UMR3525, Paris, 75015, France; Sorbonne Université, Collège Doctoral, F-75005 Paris, France.
Université Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, 38000 Grenoble, France.
Trends Microbiol. 2020 May;28(5):372-386. doi: 10.1016/j.tim.2020.01.005. Epub 2020 Feb 13.
Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adhesion. Some of these secretion systems emerged many times, whereas others are unique. In most cases, their evolution occurred by successive rounds of gene accretion, deletion, and horizontal transfer, resulting in machines that can be very different from the original ones. The frequency with which such co-option processes occurred seems to depend on the complexity of the systems, their differences to the ancestral machines, the availability of genetic material to tinker with, and possibly on the mechanisms of effector recognition. Understanding the evolution of secretion systems illuminates their functional diversification and could drive the discovery of novel systems.
蛋白质分泌对于许多生物和非生物相互作用都很重要。细菌的蛋白质分泌系统以及相关的纳米机器的进化是通过对运动、共轭、注射或粘附的机制的共同作用而发生的。其中一些分泌系统多次出现，而另一些则是独特的。在大多数情况下，它们的进化是通过基因的连续积累、删除和水平转移来实现的，从而导致机器与原始机器有很大的不同。这种共同作用过程发生的频率似乎取决于系统的复杂性、它们与祖先机器的差异、可用于修补的遗传物质的可用性，以及可能与效应物识别的机制有关。了解分泌系统的进化可以阐明其功能多样化，并可能推动新系统的发现。
