Department of Orthopedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Department of Advanced Technology in Medicine, Graduate School of Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Clin Neurophysiol. 2020 Jun;131(6):1252-1266. doi: 10.1016/j.clinph.2020.02.025. Epub 2020 Mar 19.
Magnetospinography (MSG) has been developed for clinical application and is expected to be a novel neurophysiological examination. Here, we used an MSG system with sensors positioned in three orthogonal directions to record lumbar canal evoked magnetic fields (LCEFs) in response to peripheral nerve stimulation and to evaluate methods for localizing spinal cord lesions.
LCEFs from the lumbar area of seven rabbits were recorded by the MSG system in response to electrical stimulation of a sciatic nerve. LCEFs and lumbar canal evoked potentials (LCEPs) were measured before and after spinal cord compression induced by a balloon catheter. The lesion positions were estimated using LCEPs and computationally reconstructed currents corresponding to the depolarization site.
LCEFs were recorded in all rabbits and neural activity in the lumbar spinal cord could be visualized in the form of a magnetic contour map and reconstructed current map. The position of the spinal cord lesion could be estimated by the LCEPs and reconstructed currents at the depolarization site.
MSG can visualize neural activity in the spinal cord and localize the lesion site.
MSG enables noninvasive assessment of neural activity in the spinal canal using currents at depolarization sites reconstructed from LCEFs.
磁旋描记术（MSG）已被开发用于临床应用，有望成为一种新的神经生理学检查方法。在这里，我们使用了一种具有三个正交方向传感器的 MSG 系统来记录腰椎管诱发磁场（LCEFs），以响应外周神经刺激，并评估定位脊髓病变的方法。
通过 MSG 系统记录了 7 只兔子的腰椎区对坐骨神经电刺激的 LCEFs。在使用气囊导管诱导脊髓压迫前后测量了 LCEFs 和腰椎管诱发电位（LCEPs）。使用 LCEPs 和对应去极化部位的计算重建电流来估计病变部位。
所有兔子均记录到了 LCEFs，可以以磁等高线图和重建电流图的形式显示腰椎脊髓的神经活动。LCEPs 和去极化部位重建电流可估计脊髓病变部位。
MSG 可以可视化脊髓内的神经活动并定位病变部位。
MSG 可以使用从 LCEFs 重建的去极化部位电流对椎管内的神经活动进行非侵入性评估。
