Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes. Av, Aguascalientes, México.
Department of Morphology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes. Av, Aguascalientes, México.
Growth Factors. 2020 Jan;38(1):1-15. doi: 10.1080/08977194.2020.1753724. Epub 2020 Apr 17.
Trophic factors are naturally produced by different tissues that participate in several functions such as the intercellular communication, in the development, stability, differentiation and regeneration at the cellular level. Specifically, in the case of spinal injuries, these factors can stimulate neuronal recovery. They are applied both in experimental models and in clinical trials in patients. The trophic factors analysed in this review include gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), growth hormone (GH), melatonin, oestrogens, the family of fibroblast growth factors (FGFs), the family of neurotrophins and the glial cell-derived neurotrophic factor (GDNF). There are some trophic (neurotrophic) factors that already been tested in patients with spinal cord injury (SCI), but only shown partial recovery effect. It is possible that, the administration of these trophic factors together with physical rehabilitation, act synergistically and, therefore, significantly improve the quality of life of patients with SCI.
营养因子是由参与多种功能的不同组织自然产生的，如细胞间通讯、发育、稳定性、分化和细胞水平的再生。具体来说，在脊髓损伤的情况下，这些因子可以刺激神经元的恢复。它们既应用于实验模型，也应用于患者的临床试验。本综述分析的营养因子包括促性腺激素释放激素（GnRH）、促甲状腺素释放激素（TRH）、生长激素（GH）、褪黑素、雌激素、成纤维细胞生长因子（FGF）家族、神经营养因子家族和胶质细胞源性神经营养因子（GDNF）。有一些营养（神经营养）因子已经在脊髓损伤（SCI）患者中进行了测试，但只显示出部分恢复效果。这些营养因子与物理康复联合应用，可能协同作用，从而显著提高 SCI 患者的生活质量。
