Department of Neuropsychiatry, Teikyo University School of Medicine, Tokyo, Japan.
J Int Med Res. 2020 Apr;48(4):300060520917270. doi: 10.1177/0300060520917270.
To investigate the utility of the voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD).
Clinical data from patients who underwent screening for dementia using VSRAD and the Japanese version of COGNISTAT, the Neurobehavioral Cognitive Status Examination, were retrospectively investigated to specify the domains of cognitive function that correlate with the statistical mean value of positive Z-scores in the target volume-of-interest (VOI). A receiver operating characteristic (ROC) curve was constructed to assess the mean value of positive Z-scores in discriminating patients with AD.
A total of 72 patients were included (18 male and 54 female; 15 patients with AD). The mean value of positive Z-scores in the target VOI was significantly correlated with standardized COGNISTAT scores for Orientation and Memory in all patients (r = –0.35 and –0.38, respectively). ROC curve analysis revealed that a cut-off of 1.57 for mean value of positive Z-scores in the target VOI provided 69.4% accuracy in discriminating patients with AD, with a sensitivity of 0.80 and specificity of 0.67.
The results evinced the value of VSRAD in diagnosing AD. The degree of atrophy represented by the target VOI may reflect impairments in Orientation and Memory, which are early stage symptoms observed in AD.
研究基于体素的阿尔茨海默病特定区域分析系统（VSRAD）的效用。
回顾性调查了使用 VSRAD 和日本版 COGNISTAT（神经行为认知状态检查）进行痴呆筛查的患者的临床数据，以确定与目标感兴趣区（VOI）中阳性 Z 分数统计平均值相关的认知功能域。构建了受试者工作特征（ROC）曲线，以评估阳性 Z 分数平均值在区分 AD 患者中的作用。
共纳入 72 例患者（男 18 例，女 54 例，AD 患者 15 例）。在所有患者中，目标 VOI 中阳性 Z 分数的平均值与 COGNISTAT 定向和记忆标准化评分显著相关（分别为 r=–0.35 和 –0.38）。ROC 曲线分析显示，目标 VOI 中阳性 Z 分数平均值为 1.57 的截断值可提供 69.4%的 AD 患者鉴别准确性，其灵敏度为 0.80，特异性为 0.67。
研究结果表明 VSRAD 对 AD 的诊断具有价值。目标 VOI 代表的萎缩程度可能反映了定向和记忆方面的损伤，这些是 AD 中早期观察到的症状。
