Olivieri L, Pierdominici S, Testa G, Borzomati E, Battisti G, Arrabito G, Caporale A, Giuliani A
Istituto di Anestesia e Rianimazione, Università La Sapienza, Roma.
Ital J Surg Sci. 1988;18(3):217-21.
This study, carried out in 62 patients undergoing surgery under general anaesthesia, has evaluated the nestigmine effects on tone and motility of the muscular rectal wall, by recording compliance and manometric values. An increase of intrarectal pressure values in patients antagonized with neostigmine has been evidenced. This finding is related to contracture and increased motility of muscular rectal wall, induced by anticholinesterase agent. In patients eligible for intestinal anastomoses, rapidly eliminated myoneural blocker such as atracurium besylate or vecuronium, should be preferred. These agents allow a spontaneous reversal of the myoneural block, without pharmacologic antagonism.
本研究对62例接受全身麻醉手术的患者进行，通过记录顺应性和测压值，评估了新斯的明对直肠肌壁张力和运动性的影响。已证实新斯的明拮抗的患者直肠内压值升高。这一发现与抗胆碱酯酶药物引起的直肠肌壁挛缩和运动性增加有关。对于适合进行肠吻合术的患者，应首选快速消除的神经肌肉阻滞剂，如阿曲库铵苯磺酸盐或维库溴铵。这些药物可使神经肌肉阻滞自发逆转，无需药物拮抗。
