Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Department of Medicine, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
Arch Osteoporos. 2020 Apr 17;15(1):57. doi: 10.1007/s11657-020-00722-7.
Bone turnover markers (BTMs) are not widely used in clinical decision-making partly due to the wide variation of the reference values. This paper describes the geographical variation in BTMs reported from Asian countries.
A systematic search was conducted using the PubMed, EMBASE, and Ovid. We searched for BTMs or individual BTMs in Asia or different countries in the Asian region. Original research which published BTM values were included while reviews, comments, and meta-analyses were excluded.
Of 650 articles, 23 fulfilled the selection criteria and were considered for this study. Among premenopausal women, mean intact OC ranged from 3.35 in Japan to 7.38 ng/mL (55%) in Thailand while it ranged between 3.35 and 5.8 ng/mL (42%) within Japan. Mean BALP varied from 15.9 in India to 41.2 U/L (61%) in Japan whereas in India, it ranged between 15.9 and 53.7 U/L (70%). Mean sP1NP ranged from 29.5 in Japan to 38.02 ng/mL in China (22%) whereas sCTX varied from 0.26 in Thailand to 0.099 ng/mL (62%) in Japan. Among postmenopausal women, mean total OC ranged from 10.02 in India to 29.8 ng/mL (66%) in Japan and intact OC ranged between 2.69 and 9.49 ng/mL (72%) within China. Mean BALP ranged from 20.9 in Japan to 60.28 U/L (65%) in China, and within China, it ranged from 28.2 to 60.28 U/L (53%). Mean sP1NP ranged from 40.11 in China to 56.4 ng/mL (29%) in Japan whereas it ranged within China from 40.11 to 53.76 ng/mL (25%). Mean sCTX varied from 0.25 to 0.433 ng/mL (42%) between the same countries respectively while within China, it varied from 0.25 to 0.395 ng/mL (37%). Urinary BTMs showed a lesser variation.
A wide inter-country and intra-country variation of serum BTMs was observed among pre and postmenopausal women in Asia. Differences in selection criteria of subjects and those inherited to analytical methods may have contributed to these differences.
骨转换标志物（BTM）在临床决策中的应用并不广泛，部分原因是其参考值的差异较大。本文描述了亚洲国家报告的 BTM 地域差异。
使用 PubMed、EMBASE 和 Ovid 进行系统检索。我们检索了亚洲或亚洲不同国家的 BTM 或单个 BTM 的研究。纳入了发表 BTM 值的原始研究，排除了综述、评论和荟萃分析。
在 650 篇文章中，有 23 篇符合选择标准，被纳入本研究。在绝经前女性中，完整 OC 的平均水平范围从日本的 3.35ng/ml（55%）到泰国的 7.38ng/ml，而在日本，其范围为 3.35-5.8ng/ml（42%）。BALP 的平均水平范围从印度的 15.9U/L 到日本的 41.2U/L（61%），而在印度，其范围为 15.9-53.7U/L（70%）。sP1NP 的平均水平范围从日本的 29.5ng/ml 到中国的 38.02ng/ml（22%），而 sCTX 的水平范围从泰国的 0.26ng/ml 到日本的 0.099ng/ml（62%）。在绝经后女性中，总 OC 的平均水平范围从印度的 10.02ng/ml 到日本的 29.8ng/ml（66%），完整 OC 的水平范围在 2.69-9.49ng/ml（72%）。BALP 的平均水平范围从日本的 20.9U/L 到中国的 60.28U/L（65%），而在中国，其范围从 28.2U/L 到 60.28U/L（53%）。sP1NP 的平均水平范围从中国的 40.11ng/ml 到日本的 56.4ng/ml（29%），而在中国，其范围从 40.11ng/ml 到 53.76ng/ml（25%）。sCTX 的平均水平范围从 0.25-0.433ng/ml（42%），分别在同一国家之间有所不同，而在中国，其范围从 0.25-0.395ng/ml（37%）。尿 BTM 显示出较小的差异。
在亚洲绝经前和绝经后女性中，血清 BTM 存在广泛的国家间和国家内差异。研究对象选择标准的差异以及分析方法的固有差异可能导致了这些差异。
