Faculty of Medicine, Bangkokthonburi University, Bangkok 10170, Thailand.
Child Safety Promotion and Injury Prevention Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
Nutrients. 2021 Nov 25;13(12):4226. doi: 10.3390/nu13124226.
Vitamin E is a strong anti-oxidative stress agent that affects the bone remodeling process. This study evaluates the effect of mixed-tocopherol supplements on bone remodeling in postmenopausal osteopenic women. A double-blinded, randomized, placebo-controlled trial study was designed to measure the effect of mixed-tocopherol on the bone turnover marker after 12 weeks of supplementation. All 52 osteopenic postmenopausal women were enrolled and allocated into two groups. The intervention group received mixed-tocopherol 400 IU/day, while the control group received placebo tablets. Fifty-two participants completed 12 weeks of follow-up. Under an intention-to-treat analysis, vitamin E produced a significant difference in the mean bone resorption marker (serum C-terminal telopeptide of type I collagen (CTX)) compared with the placebo group (-0.003 ± 0.09 and 0.121 ± 0.15, respectively ( < 0.001)). In the placebo group, the CTX had increased by 35.3% at 12 weeks of supplementation versus baseline ( < 0.001), while, in the vitamin E group, there was no significant change of bone resorption marker ( < 0.898). In conclusion, vitamin E (mixed-tocopherol) supplementation in postmenopausal osteopenic women may have a preventive effect on bone loss through anti-resorptive activity.
维生素 E 是一种强大的抗氧化应激剂，影响着骨重塑过程。本研究评估了混合生育酚补充剂对绝经后骨质疏松女性骨重塑的影响。设计了一项双盲、随机、安慰剂对照试验研究，以测量混合生育酚对补充 12 周后骨转换标志物的影响。所有 52 例骨质疏松绝经后妇女均被纳入并分为两组。干预组每天服用混合生育酚 400IU，而对照组服用安慰剂片。52 名参与者完成了 12 周的随访。在意向治疗分析中，与安慰剂组相比，维生素 E 对平均骨吸收标志物（血清 I 型胶原 C 端肽（CTX））产生了显著差异（-0.003 ± 0.09 和 0.121 ± 0.15，分别为 < 0.001）。在安慰剂组中，CTX 在补充 12 周时与基线相比增加了 35.3%（<0.001），而在维生素 E 组中，骨吸收标志物没有明显变化（<0.898）。结论：在绝经后骨质疏松女性中补充维生素 E（混合生育酚）可能通过抗吸收作用对骨丢失具有预防作用。
