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HIV 阳性器官移植时代的供者评估:传染病专家的重要性。

Donor evaluation in the era of HIV-positive organ transplantation: The importance of the infectious diseases specialist.

机构信息

Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.

Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA.

出版信息

Am J Transplant. 2020 Sep;20(9):2589-2592. doi: 10.1111/ajt.15921. Epub 2020 May 8.

Abstract

A 61-year-old female with well-controlled human immunodeficiency virus (HIV) and end-stage renal disease was on the kidney transplant waitlist awaiting an organ offer, including from HIV-positive donors through the HIV Organ Policy Equity (HOPE) Act. We present three different scenarios where HIV-positive donor offers were evaluated for this one recipient, discuss the donor evaluation process, explain where the infectious diseases provider fits in this scheme, and describe the challenges encountered by organ procurement organizations. This is the first case under the HOPE Act at our center where discovery of an HIV-specific issue led to a turndown of an organ offer.

摘要

一位 61 岁的女性,患有人类免疫缺陷病毒(HIV)且病情得到良好控制,同时患有终末期肾病,正在等待肾脏移植。她等待器官捐赠,包括通过《HIV 器官政策公平(HOPE)法案》接受 HIV 阳性供体的器官捐赠。我们提出了三种不同的情况,评估了 HIV 阳性供体对这一个体受者的捐赠,讨论了供体评估过程,解释了传染病提供者在该方案中的作用,并描述了器官获取组织所面临的挑战。这是我们中心首例根据《HOPE 法案》进行的案例,在此案中,HIV 相关问题的发现导致器官捐赠被拒绝。

相似文献

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HIV-Positive-to-HIV-Positive Liver Transplantation.HIV阳性者之间的肝移植
Am J Transplant. 2016 Aug;16(8):2473-8. doi: 10.1111/ajt.13824. Epub 2016 Jun 7.

本文引用的文献

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HIV-Positive Kidney Donor Selection for HIV-Positive Transplant Recipients.HIV 阳性供肾者选择用于 HIV 阳性移植受者。
J Am Soc Nephrol. 2018 Apr;29(4):1090-1095. doi: 10.1681/ASN.2017080853. Epub 2018 Jan 12.
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Infection in Organ Transplantation.器官移植中的感染
Am J Transplant. 2017 Apr;17(4):856-879. doi: 10.1111/ajt.14208. Epub 2017 Mar 10.

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