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小儿克罗恩病患者开放性与腹腔镜右半结肠切除术的比较

Open Versus Laparoscopic Right Hemicolectomies in Pediatric Patients with Crohn's Disease.

作者信息

Quiroz Hallie J, Perez Eduardo A, El Tawil Rana A, Willobee Brent A, Galvez-Cabezas Kevin, Ferrantella Anthony R, Thorson Chad M, Langshaw Amber H, Sola Juan E

机构信息

Division of Pediatric Surgery, DeWitt Daughtry Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA.

Department of Pediatrics, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, USA.

出版信息

J Laparoendosc Adv Surg Tech A. 2020 Jul;30(7):820-825. doi: 10.1089/lap.2019.0814. Epub 2020 Apr 16.

Abstract

Surgery remains an important treatment modality for the management of pediatric Crohn's disease (CD). The objective of this study was to perform a comparative analysis of open right hemicolectomy (ORH) and laparoscopic right hemicolectomy (LRH) for the management of pediatric CD. The Kids' Inpatient Database (KID) was queried (2009-2012) for ICD-9 procedure codes for ORH (45.73) and LRH (17.33) in patients with CD (ICD-9 codes: 555.0, 555.1, 555.2, 555.9). Open and laparoscopic procedures were compared using propensity score (PS)-matched analysis (PSMA) of 41 variables. Overall 889 patients were identified and after PS matching, there were 380 ORHs and 380 LRHs. There were zero in-hospital deaths (0/821). ORH patients were more likely to have septicemia, respiratory compromise, pneumonia, perforation and/or laceration, complications, and require blood transfusions (all,  < .05). Although LRH patients were more likely to develop postoperative nausea/vomiting/diarrhea ( < .0001), they had a shorter hospital length of stay ( < .0001) and lower overall hospital charges and cost ( < .001). ORH and LRH in KID have similar low in-hospital mortality in pediatric CD. However, ORH was associated with higher morbidity including an increased risk for respiratory complications, surgical complications, need for blood transfusions, and increased resource utilization than patients who had laparoscopic procedures. In select patients, LRH is safe, feasible, and potentially superior to ORH.

摘要

手术仍然是小儿克罗恩病(CD)治疗的重要方式。本研究的目的是对开放式右半结肠切除术(ORH)和腹腔镜右半结肠切除术(LRH)治疗小儿CD进行对比分析。查询儿童住院数据库(KID,2009 - 2012年)中CD患者(国际疾病分类第九版[ICD - 9]编码:555.0、555.1、555.2、555.9)的ORH(45.73)和LRH(17.33)的ICD - 9手术编码。采用倾向评分(PS)匹配分析(PSMA)对41个变量进行开放式和腹腔镜手术对比。共识别出889例患者,PS匹配后,有380例ORH和380例LRH。住院死亡0例(0/821)。ORH患者更易发生败血症、呼吸功能不全、肺炎、穿孔和/或撕裂伤、并发症,且需要输血(均P<0.05)。虽然LRH患者更易发生术后恶心/呕吐/腹泻(P<0.0001),但其住院时间较短(P<0.0001),总体住院费用和成本较低(P<0.001)。KID中的ORH和LRH在小儿CD中的住院死亡率相似。然而,与接受腹腔镜手术的患者相比,ORH的发病率更高,包括呼吸并发症、手术并发症、输血需求增加以及资源利用增加的风险。在特定患者中,LRH安全、可行,且可能优于ORH。

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