二腈介导的活性氧积累导致细菌生长抑制。
Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition.
机构信息
State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
出版信息
J Nat Prod. 2020 May 22;83(5):1634-1640. doi: 10.1021/acs.jnatprod.0c00125. Epub 2020 Apr 17.
The diisonitrile copper chelator SF2768 biosynthesized by functions as a chalkophore that transports extracellular copper into producer cells in a complexed form. It was demonstrated that the treatment of eight bacteria, including and , with SF2768 led to a moderate growth inhibition which is associated with an increased level of reactive oxygen species (ROS). In addition, SF2768 and its diisonitrile analogues proved to be effective tyrosinase inhibitors. Three new analogues, SF2768 I, K, and L, were identified by detailed spectroscopic analysis.
二腈铜螯合剂 SF2768 由 产生，作为一种 chalkophore，将细胞外的铜以复合物的形式运输到生产细胞中。研究表明，SF2768 处理包括 和 在内的 8 种细菌，导致中度生长抑制，与活性氧（ROS）水平升高有关。此外，SF2768 及其二腈类似物被证明是有效的酪氨酸酶抑制剂。通过详细的光谱分析，鉴定了三个新的类似物 SF2768 I、K 和 L。
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