Johansson A, Camner P, Curstedt T, Jarstrand C, Robertson B, Urban T
Department of Environmental Hygiene, Karolinska Institute, Stockholm, Sweden.
J Appl Toxicol. 1988 Oct;8(5):373-5. doi: 10.1002/jat.2550080507.
Rabbits were exposed to aerosols of lithium chloride in metal concentrations of 0.6 and 1.9 mg/m3 (mass median aerodynamic diameter of 1 micron) for 4-8 weeks, 5 days/week, 6 h/day. The lungs were studied by light and electron microscopy, with particular reference to inflammatory changes, structure of alveolar macrophages and alveolar epithelial cells. Macrophages recovered by lung lavage were studied by light and electron microscopy and their oxidative metabolic activity was measured. The content of phospholipids was analysed in lung tissue. Exposure to lithium produced no significant effects. It thus seems that Li+ is less toxic to the lung than the other metals investigated with the same test system, e.g. Ni2+, Cd2+, Co2+, Cr3+ and Cr6+.
将兔子暴露于金属浓度分别为0.6毫克/立方米和1.9毫克/立方米（质量中位空气动力学直径为1微米）的氯化锂气溶胶中，每周5天，每天6小时，持续4至8周。通过光学显微镜和电子显微镜对肺部进行研究，特别关注炎症变化、肺泡巨噬细胞和肺泡上皮细胞的结构。对通过肺灌洗回收的巨噬细胞进行光学显微镜和电子显微镜研究，并测量其氧化代谢活性。分析肺组织中磷脂的含量。锂暴露未产生显著影响。因此，在相同测试系统中，Li+似乎比其他研究的金属（如Ni2+、Cd2+、Co2+、Cr3+和Cr6+）对肺的毒性更小。
