生物凝聚体中的网络和动态开关。

Networking and Dynamic Switches in Biological Condensates.

机构信息

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Cell. 2020 Apr 16;181(2):228-230. doi: 10.1016/j.cell.2020.03.056.

DOI:10.1016/j.cell.2020.03.056

PMID:32302565

Abstract

Cellular liquid-liquid phase separation (LLPS) plays a key role in the dynamics and function of RNA-protein condensates like stress granules. In this issue of Cell, Yang et al., Guillén-Boixet et al., and Sanders et al. use a combination of experiment and modeling to provide an exciting mechanistic insight into the relationship between stress granules and LLPS, for example, in the context of protein disorder, switchable interactions, graph theory, and multiple interacting dense phases.

摘要

细胞液-液相分离 (LLPS) 在 RNA-蛋白质凝聚物（如应激颗粒）的动态和功能中起着关键作用。在本期《Cell》中，Yang 等人、Guillén-Boixet 等人和 Sanders 等人结合实验和建模，为应激颗粒和 LLPS 之间的关系提供了令人兴奋的机制见解，例如在蛋白质无序、可切换相互作用、图论和多个相互作用的密集相的背景下。