Department of Medicine, McGill University, McGill International TB Centre, Montreal H4A 3J1, Canada.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Cell. 2020 Apr 16;181(2):230-232. doi: 10.1016/j.cell.2020.03.057.
Cough, a hallmark of tuberculosis, transmits the disease. Ruhl et al. find that a Mycobacterium tuberculosis (Mtb)-specific lipid, SL-1, stimulates human nociceptive neurons and makes guinea pigs cough. Mtb extract, but not SL-1, also stimulates non-nociceptive neurons that participate in the cough reflex, suggesting additional cough-inducing mechanisms.
咳嗽是结核病的一个标志，可传播这种疾病。Ruhl 等人发现结核分枝杆菌（Mycobacterium tuberculosis，Mtb）特异性脂质 SL-1 可刺激人类伤害感受神经元并引起豚鼠咳嗽。Mtb 提取物而非 SL-1 还可刺激参与咳嗽反射的非伤害感受神经元，提示存在其他引起咳嗽的机制。
