Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Badalona, Spain.
Doctoral Programme in Biomedicine, Universitat de Barcelona, Barcelona, Spain.
Reproduction. 2020 Jun;159(6):R251-R263. doi: 10.1530/REP-19-0340.
During the past half century, evidence for inheritance of variable traits has accumulated from experiments in plants and animals and epidemiological studies in humans. Here, we summarize some of the reported cases of epigenetic inheritance and the proposed mechanisms involved in the transmission of non-genetic information between generations in plants, nematodes, flies and mammals. It has long been accepted that information is epigenetically inherited in plants. Although many questions regarding the underlying mechanisms remain to be answered, it is now evident that epigenetic mechanisms are also responsible for the transmission of phenotypes in animals. We highlight similarities and differences between models and species.
在过去的半个世纪中，来自植物和动物实验以及人类流行病学研究的证据积累了可变特征遗传的证据。在这里，我们总结了一些已报道的表观遗传遗传案例，以及在植物、线虫、苍蝇和哺乳动物中，在世代之间传递非遗传信息所涉及的提出的机制。长期以来，人们一直认为植物中的信息是通过表观遗传方式遗传的。尽管关于潜在机制的许多问题仍有待回答，但现在显然，表观遗传机制也负责动物表型的传递。我们强调了模型和物种之间的相似之处和差异。
