NAD(P)H 醌氧化还原酶 1 rs1800566 多态性与膀胱癌和前列腺癌的关系：系统评价和荟萃分析。
Association of NAD (P) H Quinine Oxidoreductase 1 rs1800566 Polymorphism with Bladder and Prostate Cancers - a Systematic Review and Meta-Analysis.
出版信息
Klin Onkol. 2020 Spring;33(2):92-100. doi: 10.14735/amko202092.
BACKGROUND
Number of studies has been performed to investigate the association of NAD (P) H quinine oxidoreductase 1 (NQO1) rs1800566 polymorphism with risk of bladder and prostate cancers, but presented inconsistent results. Therefore, we performed a meta-analysis to provide a comprehensive data on the association of NQO1 rs1800566 polymorphism with bladder and prostate cancers.
METHODS
All eligible studies were identified in PubMed, Google Scholar, EMBASE, and China National Knowledge Infrastructure databases before June 01, 2019.
RESULTS
A total of 22 case-control studies including 15 studies with 4,413 cases and 4,275 controls on bladder cancer and 7 studies with 762 cases and 1,813 controls on prostate cancer were selected. Overall, pooled data showed that the NQO1 rs1800566 polymorphism was significantly associated with an increased risk of bladder cancer (T vs. C: OR 1.300; 95% CI 1.112-1.518; P = 0.001; TT vs. CC: OR 1.415; 95% CI 1.084-1.847; P = 0.011; TC vs. CC: OR 1.389; 95% CI 1.111-1.738; P = 0.004; TT + TC vs. CC: OR 1.428; 95% CI 1.145-1.782; P = 0.002) and prostate cancer (TC vs. CC: OR 1.276; 95% CI 1.047-1.555; P = 0.016; TT + TC vs. CC: OR 1.268; 95% CI 1.050-1.532; P = 0.014). The stratified analysis by ethnicity revealed an increased risk of bladder cancer among Caucasians and prostate cancer among Asians.
CONCLUSION
This meta-analysis suggested that the NQO1 rs1800566 polymorphism was significantly associated with increased risk of bladder and prostate cancers.
背景
已经有许多研究调查了 NAD(P)H 醌氧化还原酶 1（NQO1）rs1800566 多态性与膀胱癌和前列腺癌风险之间的关联，但结果不一致。因此，我们进行了一项荟萃分析，以提供关于 NQO1 rs1800566 多态性与膀胱癌和前列腺癌关联的综合数据。
方法
我们在 2019 年 6 月 1 日之前在 PubMed、Google Scholar、EMBASE 和中国国家知识基础设施数据库中检索了所有符合条件的研究。
结果
共纳入 22 项病例对照研究，其中 15 项研究纳入了 4413 例膀胱癌病例和 4275 例对照，7 项研究纳入了 762 例前列腺癌病例和 1813 例对照。总体而言，汇总数据显示，NQO1 rs1800566 多态性与膀胱癌风险增加显著相关（T 对 C：OR 1.300；95%CI 1.112-1.518；P=0.001；TT 对 CC：OR 1.415；95%CI 1.084-1.847；P=0.011；TC 对 CC：OR 1.389；95%CI 1.111-1.738；P=0.004；TT+TC 对 CC：OR 1.428；95%CI 1.145-1.782；P=0.002）和前列腺癌（TC 对 CC：OR 1.276；95%CI 1.047-1.555；P=0.016；TT+TC 对 CC：OR 1.268；95%CI 1.050-1.532；P=0.014）。按种族进行的分层分析显示，NQO1 rs1800566 多态性与白种人膀胱癌风险增加和亚洲人前列腺癌风险增加相关。
结论
这项荟萃分析表明，NQO1 rs1800566 多态性与膀胱癌和前列腺癌风险增加显著相关。
Zotero 插件