Wnt/β-连环蛋白在急性肾损伤及向慢性肾脏病进展中的作用。
Wnt/β-Catenin in Acute Kidney Injury and Progression to Chronic Kidney Disease.
机构信息
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN.
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department of Medicine, Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, TN; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN.
出版信息
Semin Nephrol. 2020 Mar;40(2):126-137. doi: 10.1016/j.semnephrol.2020.01.004.
Abstract
Acute kidney injury (AKI) portends a poor clinical prognosis and increases the risk for the development of chronic kidney disease (CKD). Currently, there are no therapies to treat AKI or prevent its progression to CKD. Wnt/β-catenin is a critical regulator of kidney development that is up-regulated after injury. Most of the literature support a beneficial role for Wnt/β-catenin in AKI, but suggest that this pathway promotes the progression of tubulointerstitial fibrosis, the hallmark of CKD progression. We review the role of Wnt/β-catenin in renal injury with a focus on its potential as a therapeutic target in AKI and in AKI to CKD transition.
摘要
急性肾损伤 (AKI) 预示着不良的临床预后，并增加了慢性肾脏病 (CKD) 的发展风险。目前，尚无治疗 AKI 或预防其进展为 CKD 的疗法。Wnt/β-catenin 是肾脏发育的关键调节因子，损伤后会被上调。大多数文献支持 Wnt/β-catenin 在 AKI 中的有益作用，但表明该途径促进了 CKD 进展的标志性肾小管间质纤维化的进展。我们回顾了 Wnt/β-catenin 在肾脏损伤中的作用，重点关注其作为 AKI 治疗靶点以及 AKI 向 CKD 转化中的潜在作用。
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