Central Veterinary Research Laboratory, Dubai, UAE.
Central Veterinary Research Laboratory, Dubai, UAE.
J Equine Vet Sci. 2020 May;88:102967. doi: 10.1016/j.jevs.2020.102967. Epub 2020 Mar 5.
Our investigation has shown that multiple vaccinations with inactivated African horse sickness (AHS) vaccines containing all 9 serotypes and produced at the Central Veterinary Research Laboratory in Dubai, UAE, protect horses from AHS. However, the immunization did not prevent African horse sickness fever (AHSF) in approximately 10% of the vaccinated horses despite high enzyme-linked immunosorbent assay and virus neutralizing antibodies. African horse sickness fever is a very mild form of AHS with similar clinical signs. From all 6 horses which had developed AHSF, no virus was isolated from EDTA blood withdrawn during the acute phase of infection. Despite high neutralizing antibodies, serotype 9 was detected by polymerase chain reaction in 4 of them. All 6 horses recovered within 72 hours, after they developed mild clinical signs of AHS.
我们的调查表明，多次接种在阿联酋迪拜的中央兽医研究所生产的含有所有 9 种血清型的灭活的非洲马瘟（AHS）疫苗可保护马免受 AHS 感染。然而，尽管酶联免疫吸附试验和病毒中和抗体水平很高，但仍有约 10%的接种疫苗的马患上了非洲马瘟热（AHSF）。非洲马瘟热是一种非常轻微的 AHS 形式，具有相似的临床症状。在所有发生 AHSF 的 6 匹马中，在感染急性期从 EDTA 血中未分离到病毒。尽管中和抗体水平很高，但在其中 4 匹马中通过聚合酶链反应检测到了血清型 9。所有 6 匹马在出现轻度 AHS 临床症状后 72 小时内均康复。
