Diaz Mark Anthony, Bayo Maria Luisa, Alvarez Francisco, Alvarez Salvador
Division of Infectious Diseases, Mayo Clinic, Jacksonville, Florida, USA.
University of Navarra, Pamplona, Navarra, Spain.
BMJ Case Rep. 2020 Apr 16;13(4):e230888. doi: 10.1136/bcr-2019-230888.
A middle-aged woman was hospitalised for generalised, painful skin lesions 6 weeks after a successful double-lung transplant. She had end-stage lung disease associated with chronic obstructive pulmonary disease due to alpha-1 antitrypsin deficiency, and she had been treated with itraconazole for 16 months because of lung infection associated with spp. Results of a skin biopsy of the initial lesion on her arm showed non-specific dermal inflammation, presumably due to reactivation of the spp infection. Follow-up cervical lymph node biopsy and culture showed / A detailed review of her travel history showed a 4-month stay in Arizona as a teenager that she barely remembered. spp were likely misidentified as spp owing to similar morphological characteristics. Dosages of immunosuppressive medications were reduced, and antifungal therapy was changed to posaconazole. Her skin lesions resolved.
一名中年女性在双肺移植成功6周后因全身性疼痛性皮肤病变入院。她患有终末期肺病,与α-1抗胰蛋白酶缺乏所致的慢性阻塞性肺疾病相关,因肺部感染曾接受16个月的伊曲康唑治疗。对其手臂上最初病变进行的皮肤活检结果显示为非特异性真皮炎症,推测是由于 spp感染的重新激活。后续颈部淋巴结活检和培养显示 / 对其旅行史的详细回顾显示,她十几岁时在亚利桑那州待过4个月,她几乎已不记得此事。由于形态特征相似, spp可能被误鉴定为 spp。免疫抑制药物剂量减少,抗真菌治疗改为泊沙康唑。她的皮肤病变得到缓解。