International Academy of Targeted Therapeutics and Innovation, Chongqing University of Arts and Sciences, Chongqing, P. R. China.
Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.
Adv Exp Med Biol. 2020;1260:1-12. doi: 10.1007/978-3-030-42667-5_1.
The control of crosstalk between autophagy and apoptosis in tumor cells can remove a critical barrier to comprehensive and efficacious treatment for cancer. Reactive oxygen species (ROS), by-products of redox homeostasis, are critical for regulating the balance between autophagy and apoptosis in cancer cells upon different drug treatments and gene modifications. The mechanisms and consequences involved in ROS-mediated crosstalk between apoptosis and autophagy are extremely complex in cancer cells. Here, we mainly discuss the closely linked relationship between ROS levels, autophagy, and apoptosis in cancer therapy.
肿瘤细胞中自噬和细胞凋亡之间串扰的控制可以消除癌症综合有效治疗的一个关键障碍。活性氧（ROS）是氧化还原平衡的副产物，对于不同药物治疗和基因修饰后癌细胞中自噬和细胞凋亡之间的平衡调节至关重要。ROS 介导的细胞凋亡和自噬之间串扰涉及的机制和后果在癌细胞中极其复杂。在这里，我们主要讨论 ROS 水平、自噬和细胞凋亡在癌症治疗中的紧密联系。
