血清皮质醇和糖皮质激素受体基因（NR3C1）多态性与人类糖代谢异常。
Serum cortisone and glucocorticoid receptor gene (NR3C1) polymorphism in human dysglycemia.
机构信息
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
出版信息
Hormones (Athens). 2020 Sep;19(3):385-393. doi: 10.1007/s42000-020-00196-9. Epub 2020 Apr 17.
PURPOSE
We aimed to explore the associations of serum cortisone and glucocorticoid receptor (GR) polymorphism with glucose metabolism and type 2 diabetes mellitus (T2DM) among Chinese adults.
METHODS
A total of 2315 participants were included in the present study. Serum cortisone was measured by liquid chromatography-tandem mass spectrometry. Multivariable logistic regression and linear regression were employed to assess the associations between serum cortisone and different glucose metabolism status.
RESULTS
Serum cortisone was positively associated with impaired fasting glucose (IFG) and T2DM ((Quartile 4 vs Quartile 1, odds ratio (OR) = 1.36, 95% confidence interval (CI) 1.01, 1.84, and OR = 2.08, 95% CI 1.50, 2.89, respectively)). A 100% increase in cortisone was associated with a 0.015 (95% CI 0.005, 0.025) mg/dl higher fasting plasma glucose (FPG), a 0.007 (95% CI 0.001, 0.013) higher glycosylated hemoglobin (HbA1c), a 0.4% (95% CI - 0.007, 0.000) lower HOMA2-IR, and a 58.1% (95% CI - 0.788, - 0.373) lower HOMA2-β. After stratification by genotype, the association between serum cortisone and T2DM was not significant in TT genotype carriers. In addition, at the higher concentrations of cortisone, TT genotype carriers had a lower FPG, HbA1c, and HOMA2-IR and a higher HOMA2-β than GG and GT carriers.
CONCLUSIONS
Elevated serum cortisone was associated with an increased risk of IFG and T2DM, and the associations may be modified by rs9324924 polymorphism.
目的
本研究旨在探讨中国成年人血清皮质酮和糖皮质激素受体（GR）多态性与葡萄糖代谢及 2 型糖尿病（T2DM）的关系。
方法
共纳入 2315 名参与者。采用液相色谱-串联质谱法测定血清皮质酮。采用多变量 logistic 回归和线性回归评估血清皮质酮与不同葡萄糖代谢状态之间的关系。
结果
血清皮质酮与空腹血糖受损（IFG）和 T2DM 呈正相关（第 4 四分位与第 1 四分位相比，比值比（OR）=1.36，95%置信区间（CI）为 1.01 至 1.84，OR=2.08，95%CI 为 1.50 至 2.89））。皮质酮增加 100%与空腹血浆葡萄糖（FPG）升高 0.015（95%CI 0.005，0.025）mg/dl、糖化血红蛋白（HbA1c）升高 0.007（95%CI 0.001，0.013）mg/dl、HOMA2-IR 降低 0.4%（95%CI -0.007，0.000）和 HOMA2-β 降低 58.1%（95%CI -0.788，-0.373）相关。按基因型分层后，TT 基因型携带者血清皮质酮与 T2DM 之间的相关性不显著。此外，在皮质酮浓度较高的情况下，TT 基因型携带者的 FPG、HbA1c 和 HOMA2-IR 较低，HOMA2-β 较高，而 GG 和 GT 携带者则相反。
结论
血清皮质酮升高与 IFG 和 T2DM 的风险增加相关，而这种相关性可能受到 rs9324924 多态性的影响。
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