Mazgelytė Eglė, Burokienė Neringa, Vysocka Agata, Narkevičius Martynas, Petrėnas Tomas, Kaminskas Andrius, Songailienė Jurgita, Utkus Algirdas, Karčiauskaitė Dovilė
Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, M. K. Čiurlionio st. 21, LT-03101 Vilnius, Lithuania.
Clinics of Internal Diseases, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, M. K. Čiurlionio st. 21, LT-03101 Vilnius, Lithuania.
J Cardiovasc Dev Dis. 2022 Feb 27;9(3):70. doi: 10.3390/jcdd9030070.
Cardiovascular diseases (CVDs) are the major cause of death worldwide. Although the importance of conventional CVD risk factors, including older age, male gender, hypertension, obesity, dyslipidemia and hyperglycemia, is well-studied, psychosocial stress, which is considered an independent CVD risk factor, requires further investigation. Thus, we aimed to investigate the association between long-term secretion of stress-related steroid hormones, including cortisol, cortisone and dehydroepiandrosterone, and the 10-year fatal and non-fatal CVD risk estimated by the SCORE2 risk prediction algorithm, as well as traditional CVD risk factors in a group of apparently healthy women. A total of 145 women (aged 50-64 years) participating in the national CVD prevention program were enrolled in the study. Sociodemographic, lifestyle, health-related characteristics, stress, anxiety and sleep quality indicators were evaluated using specific questionnaires. Anthropometric and arterial blood pressure measures were assessed by trained personnel, lipid and glucose metabolism biomarkers were measured using routine methods, and hair steroid hormone levels were determined by ultra-high-performance liquid chromatography-tandem mass spectrometry. The results showed that higher levels of hair cortisol and cortisone are associated with increased SCORE2 values. Moreover, significant associations between hair glucocorticoids and individual cardiovascular risk factors, including obesity, hypertension, dyslipidemia and hyperglycemia, were found. These findings indicate that stress-related hair steroid hormones might be valuable biomarkers for CVD prediction and prevention.
心血管疾病（CVDs）是全球主要的死亡原因。尽管包括老年、男性、高血压、肥胖、血脂异常和高血糖在内的传统心血管疾病风险因素的重要性已得到充分研究，但被视为独立心血管疾病风险因素的心理社会压力仍需进一步研究。因此，我们旨在调查应激相关类固醇激素（包括皮质醇、可的松和脱氢表雄酮）的长期分泌与通过SCORE2风险预测算法估计的10年致命和非致命心血管疾病风险之间的关联，以及一组看似健康的女性中的传统心血管疾病风险因素。共有145名年龄在50 - 64岁之间、参与国家心血管疾病预防计划的女性纳入了本研究。使用特定问卷评估社会人口统计学、生活方式、健康相关特征、压力、焦虑和睡眠质量指标。人体测量和动脉血压测量由经过培训的人员进行评估，脂质和葡萄糖代谢生物标志物使用常规方法测量，头发类固醇激素水平通过超高效液相色谱 - 串联质谱法测定。结果表明，头发中皮质醇和可的松水平较高与SCORE2值升高有关。此外，还发现头发糖皮质激素与包括肥胖、高血压、血脂异常和高血糖在内的个体心血管风险因素之间存在显著关联。这些发现表明，与压力相关的头发类固醇激素可能是心血管疾病预测和预防的有价值生物标志物。
