Osman Omneya M, Gaafar Tagrid, Eissa Tamer S, Abdella Rana, Ebrashy Alaa, Ellithy Ahmed
Department of Obstetrics and Gynecology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Clinical and Chemical Pathology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
J Perinat Med. 2020 Jul 28;48(6):583-588. doi: 10.1515/jpm-2020-0055.
Background Hypertensive disorders of pregnancy can cause severe maternal and fetal acute morbidity and mortality. Women with pre-eclampsia have been found to have alterations in calcium and vitamin D metabolism. There are conflicting results regarding the role of vitamin D deficiency in the development of pre-eclampsia. The aim was to compare 25 (OH) D level in patients with pre-eclampsia, eclampsia and normotensive pregnant women as well as to study the prevalence of Vitamin D deficiency among the 3 groups. Patients and methods Two hundred patients with pre-eclampsia, 100 with eclampsia and 200 normotensive pregnant controls were compared as regards vitamin D level. Results Mean 25(OH)D level was lower in the pre-eclampsia (14.8 ± 5.4 ng/mL) and in the eclampsia group (10.5 ± 1.6 ng/mL) than in the pregnant controls (19.5 ± 6.5 ng/mL) (P = 0.002). This difference was only significant between the eclampsia group and the pregnant controls (P = 0.02). All eclampsia cases had vitamin D insufficiency as compared to 17.5% in the pre-eclampsia group and 39.5% in the control group. Deficiency of vitamin D (<12 ng/mL) was 47.5% in the pre-eclampsia group, 80% in the eclampsia group and only 10.5% in the control group (P = 0.035). Conclusion Vitamin D deficiency is highly prevalent among Egyptian pregnant females. Our study supports the hypothesis that low vitamin D level can play a role in the development of pre-eclampsia and eclampsia. Thus, supplementation might prevent or delay the development of pre-eclampsia and eclampsia especially in patients at a high risk.
妊娠期高血压疾病可导致严重的母婴急性发病和死亡。已发现子痫前期女性存在钙和维生素D代谢改变。关于维生素D缺乏在子痫前期发生中的作用，研究结果存在矛盾。目的是比较子痫前期、子痫和血压正常孕妇的25（OH）D水平，并研究三组中维生素D缺乏的患病率。患者与方法：比较200例子痫前期患者、100例子痫患者和200例血压正常的孕妇对照组的维生素D水平。结果：子痫前期组（14.8±5.4 ng/mL）和子痫组（10.5±1.6 ng/mL）的平均25（OH）D水平低于孕妇对照组（19.5±6.5 ng/mL）（P = 0.002）。这种差异仅在子痫组和孕妇对照组之间有统计学意义（P = 0.02）。与子痫前期组的17.5%和对照组的39.5%相比，所有子痫病例均存在维生素D不足。子痫前期组维生素D缺乏（<12 ng/mL）率为47.5%，子痫组为80%，对照组仅为10.5%（P = 0.035）。结论：维生素D缺乏在埃及孕妇中非常普遍。我们的研究支持低维生素D水平可能在子痫前期和子痫发生中起作用这一假说。因此，补充维生素D可能预防或延缓子痫前期和子痫的发生，尤其是在高危患者中。
