Area of Preventive Medicine and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Legal Medicine, School of Pharmacy, University de Valencia, Avenida Vicent Andres Estelles s/n, 46100 Valencia, Spain.
Biomedical Research Center Network on Epidemiology and Public Health (CIBERESP), Institute of Health Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain.
Nutrients. 2022 Jul 31;14(15):3166. doi: 10.3390/nu14153166.
Vitamin D has well-defined classical functions related to metabolism and bone health but also has non-classical effects that may influence pregnancy. Maternal morbidity remains a significant health care concern worldwide, despite efforts to improve maternal health. Nutritional deficiencies of vitamin D during pregnancy are related to adverse pregnancy outcomes, but the evidence base is difficult to navigate. The primary purpose of this review is to map the evidence on the effects of deficiencies of vitamin D on pregnancy outcome and the dosage used in such studies. A systematic search was performed for studies on vitamin D status during pregnancy and maternal outcomes. A total of 50 studies came from PubMed, 15 studies came from Cochrane, and 150 studies came from Embase, for a total of 215 articles. After screening, 34 were identified as candidate studies for inclusion. Finally, 28 articles met the inclusion criteria, which originated from 15 countries. The studies included 14 original research studies and 13 review studies conducted between 2012 and 2021. This review was finally limited to the 14 original studies. This systematic review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, and the quality and strength of the evidence was evaluated using the Navigation Guide Systematic Review Methodology (SING). We found evidence that supports the idea that supplementary vitamin D for pregnant women is important for reducing the risk of gestational diabetes, hypertension, preeclampsia, early labor, and other complications. The data retrieved from this review are consistent with the hypothesis that adequate vitamin D levels might contribute to a healthy pregnancy.
维生素 D 具有明确的与代谢和骨骼健康相关的经典功能，但也具有可能影响妊娠的非经典作用。尽管各国努力改善孕产妇健康，但孕产妇发病率仍然是全世界关注的一个重要的医疗保健问题。妊娠期间维生素 D 营养缺乏与不良妊娠结局有关，但证据基础难以确定。本综述的主要目的是绘制关于维生素 D 缺乏对妊娠结局的影响及其在这些研究中使用的剂量的证据图谱。对妊娠期间维生素 D 状况和孕产妇结局的研究进行了系统搜索。总共从 PubMed 检索到 50 项研究，从 Cochrane 检索到 15 项研究，从 Embase 检索到 150 项研究，共计 215 篇文章。经过筛选，确定了 34 项候选研究纳入。最终，有 28 篇文章符合纳入标准，来自 15 个国家。这些研究包括 14 项原始研究和 13 项 2012 年至 2021 年期间进行的综述研究。本综述最终仅限于 14 项原始研究。本系统评价按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行，使用导航指南系统评价方法学（SING）评估证据的质量和强度。我们发现的证据支持这样一种观点，即补充孕妇维生素 D 对于降低妊娠糖尿病、高血压、子痫前期、早产和其他并发症的风险很重要。从本综述中检索到的数据与假设一致，即适当的维生素 D 水平可能有助于健康妊娠。
