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Maternal and Pediatric Health Outcomes in relation to Gestational Vitamin D Sufficiency.与孕期维生素D充足相关的母婴健康结局
Obstet Gynecol Int. 2015;2015:501829. doi: 10.1155/2015/501829. Epub 2015 Dec 6.
2
The Relationship between Maternal Vitamin D Deficiency and Low Birth Weight Neonates.母亲维生素D缺乏与低体重新生儿之间的关系。
J Family Reprod Health. 2015 Sep;9(3):113-7.
3
Improving nutrition surveillance and public health research in Central and Eastern Europe/Balkan Countries using the Balkan Food Platform and dietary tools.利用巴尔干食品平台和膳食工具改善中东欧/巴尔干国家的营养监测和公共卫生研究。
Food Chem. 2016 Feb 15;193:173-80. doi: 10.1016/j.foodchem.2015.03.103. Epub 2015 Apr 8.
4
Establishment and advances in the online Serbian food and recipe data base harmonized with EuroFIR™ standards.建立并推进与 EuroFIR™ 标准相协调的在线塞尔维亚食品和食谱数据库。
Food Chem. 2016 Feb 15;193:30-8. doi: 10.1016/j.foodchem.2015.01.107. Epub 2015 Feb 18.
5
3-Epi-25 hydroxyvitamin D in pregnancy.孕期 3-表-25 羟维生素 D。
Pregnancy Hypertens. 2014 Jul;4(3):236. doi: 10.1016/j.preghy.2014.03.021. Epub 2014 Jul 9.
6
Validity of an FFQ assessing the vitamin D intake of young Serbian women living in a region without food fortification: the method of triads model.评估生活在无食品强化地区的塞尔维亚年轻女性维生素D摄入量的食物频率问卷的有效性：三联体模型方法
Public Health Nutr. 2016 Feb;19(3):437-45. doi: 10.1017/S136898001500138X. Epub 2015 May 11.
7
The generation of C-3α epimer of 25-hydroxyvitamin D and its biological effects on bone mineral density in adult rodents.25-羟基维生素D的C-3α差向异构体的生成及其对成年啮齿动物骨矿物质密度的生物学效应。
Calcif Tissue Int. 2015 May;96(5):453-64. doi: 10.1007/s00223-015-9973-9. Epub 2015 Feb 25.
8
Maternal and cord blood vitamin D status in high-altitude pregnancy.高海拔地区孕期的母体及脐带血维生素D状况
J Matern Fetal Neonatal Med. 2016;29(4):571-5. doi: 10.3109/14767058.2015.1011119. Epub 2015 Feb 18.
9
The relation of preeclampsia and serum level of 25-hydroxyvitamin D in mothers and their neonates: a case control study in Iran.伊朗一项病例对照研究：子痫前期与母亲及其新生儿血清25-羟基维生素D水平的关系
Horm Metab Res. 2015 Apr;47(4):284-8. doi: 10.1055/s-0034-1395607. Epub 2015 Jan 22.
10
Regulation of calcitriol biosynthesis and activity: focus on gestational vitamin D deficiency and adverse pregnancy outcomes.骨化三醇生物合成与活性的调节：关注妊娠期维生素D缺乏与不良妊娠结局
Nutrients. 2015 Jan 9;7(1):443-80. doi: 10.3390/nu7010443.

患有子痫前期的母亲及其婴儿的维生素 D 状况：来自塞尔维亚的一项病例对照研究，该国没有维生素 D 强化政策。

Vitamin D status in mothers with pre-eclampsia and their infants: a case-control study from Serbia, a country without a vitamin D fortification policy.

机构信息

1Centre of Research Excellence in Nutrition and Metabolism,Institute for Medical Research,University of Belgrade,Tadeusa Koscuska 1,11000 Belgrade,Serbia.

2School of Dietetics and Human Nutrition,McGill University,Macdonald Campus,Ste Anne-de-Bellevue,Québec,Canada.

出版信息

Public Health Nutr. 2017 Jul;20(10):1825-1835. doi: 10.1017/S1368980016000409. Epub 2016 Apr 18.

DOI:10.1017/S1368980016000409
PMID:27087002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10261584/
Abstract

OBJECTIVE

The objective of the present study was to determine if vitamin D intake and status are associated with pre-eclampsia in a country without a vitamin D fortification policy.

DESIGN

A case-control study of pregnancies with (case) and without (control) pre-eclampsia was conducted from January to April when UVB is minimal. Maternal and cord blood obtained at delivery were measured for plasma 25-hydroxycholecalciferol (25-OH-D3), 3-epimer of 25-OH-D3 (3-epi-25-OH-D3) and 24,25-dihydroxycholecalciferol (24,25-(OH)2D3) by LC-MS/MS and maternal 1,25-dihydroxyvitamin D (1,25-(OH)2D). Differences between groups were tested with ANOVA and Bonferroni post hoc tests (P<0·05).

SETTING

Clinical Center of Serbia.

SUBJECTS

Pregnant women with and without pre-eclampsia (n 60) and their infants.

RESULTS

Exogenous vitamin D intake (0·95-16·25 µg/d (38-650 IU/d)) was not significantly different between groups. Women with pre-eclampsia delivered infants at an earlier gestational age and had significantly lower mean total plasma 25-hydroxyvitamin D (25-OH-D; case: 11·2 (sd 5·1); control: 16·1 (sd 5·7) ng/ml; P=0·0006), 25-OH-D3 (case: 10·0 (sd 4·9); control: 14·2 (sd 5·8) ng/ml; P=0·002), 3-epi-25-OH-D3 (case: 0·5 (sd 0·2); control: 0·7 (sd 0·2) ng/ml; P=0·0007) and 1,25-(OH)2D (case: 56·5 (sd 26·6); control: 81·0 (sd 25·7) pg/ml; P=0·018), while 24,25-(OH)2D3 was not different between groups. Infants did not differ in total plasma 25-OH-D, 25-OH-D3, 3-epi-25-OH-D3 and 24,25-(OH)2D3, but the mean proportion of 3-epi-25-OH-D3 was higher in the infant case group (case: 7·9 (sd 1·1); control: 7·0 (sd 1·4) % of total 25-OH-D3; P=0·005).

CONCLUSIONS

A high prevalence of vitamin D deficiency, as defined by plasma 25-OH-D<12 ng/ml, was observed in 47 % of all mothers and 77 % of all infants. These data underscore the need for prenatal vitamin D supplementation and a food fortification policy in Serbia.

摘要

目的

本研究旨在确定在一个没有维生素 D 强化政策的国家，维生素 D 摄入和状态是否与子痫前期有关。

设计

对 1 月至 4 月（UVB 最少时）出现子痫前期（病例）和未出现子痫前期（对照）的妊娠进行病例对照研究。分娩时采集母血和脐血，采用 LC-MS/MS 法测定血浆 25-羟胆钙化醇（25-OH-D3）、3-差向 25-羟胆钙化醇（3-epi-25-OH-D3）和 24,25-二羟胆钙化醇（24,25-(OH)2D3），并测定母 1,25-二羟胆钙化醇（1,25-(OH)2D）。采用方差分析和 Bonferroni 事后检验（P<0·05）比较组间差异。

地点

塞尔维亚临床中心。

受试者

患有和未患有子痫前期的孕妇（n=60）及其婴儿。

结果

两组间外源性维生素 D 摄入量（0·95-16·25 µg/d（38-650 IU/d））无显著差异。患有子痫前期的孕妇分娩时胎龄更小，总血浆 25-羟胆钙化醇（25-OH-D；病例：11·2（sd 5·1）；对照：16·1（sd 5·7）ng/ml；P=0·0006）、25-OH-D3（病例：10·0（sd 4·9）；对照：14·2（sd 5·8）ng/ml；P=0·002）、3-epi-25-OH-D3（病例：0·5（sd 0·2）；对照：0·7（sd 0·2）ng/ml；P=0·0007）和 1,25-(OH)2D（病例：56·5（sd 26·6）；对照：81·0（sd 25·7）pg/ml；P=0·018）水平显著较低，而 24,25-(OH)2D3 两组间无差异。婴儿总血浆 25-OH-D、25-OH-D3、3-epi-25-OH-D3 和 24,25-(OH)2D3 水平无差异，但病例组婴儿的 3-epi-25-OH-D3 比例较高（病例：7·9（sd 1·1）；对照：7·0（sd 1·4）%的总 25-OH-D3；P=0·005）。

结论

所有母亲中有 47%、所有婴儿中有 77%存在维生素 D 缺乏（定义为血浆 25-OH-D<12ng/ml），这一数据突显了塞尔维亚产前补充维生素 D 和食品强化政策的必要性。