RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis.
作者信息
Evans Elizabeth L, Povstyan Oleksandr V, De Vecchis Dario, Macrae Fraser, Lichtenstein Laeticia, Futers T Simon, Parsonage Gregory, Humphreys Neil E, Adamson Antony, Kalli Antreas C, Ludlow Melanie J, Beech David J
机构信息
School of Medicine, University of Leeds, Leeds, United Kingdom; and.
Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Manchester, United Kingdom.
出版信息
Blood. 2020 Jul 2;136(1):140-144. doi: 10.1182/blood.2019004174.
Abstract
摘要
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RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis.红细胞可防止PIEZO1快速失活，并将缓慢失活作为脱水遗传性口形红细胞增多症的一种机制表现出来。
Blood. 2020 Jul 2;136(1):140-144. doi: 10.1182/blood.2019004174.
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Calcium Channels and Calcium-Regulated Channels in Human Red Blood Cells.人红细胞中的钙通道和钙调节通道。
Adv Exp Med Biol. 2020;1131:625-648. doi: 10.1007/978-3-030-12457-1_25.
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Force Sensing by Piezo Channels in Cardiovascular Health and Disease.压电通道在心血管健康和疾病中的力感应
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Advances in understanding the pathogenesis of red cell membrane disorders.红细胞膜疾病发病机制研究进展。
Br J Haematol. 2019 Oct;187(1):13-24. doi: 10.1111/bjh.16126. Epub 2019 Jul 31.
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Mutations in PIEZO2 contribute to Gordon syndrome, Marden-Walker syndrome and distal arthrogryposis: A bioinformatics analysis of mechanisms.PIEZO2基因的突变与戈登综合征、马登-沃克综合征和远端关节挛缩症有关：机制的生物信息学分析
Exp Ther Med. 2019 May;17(5):3518-3524. doi: 10.3892/etm.2019.7381. Epub 2019 Mar 13.
5
Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M.与PIEZO1突变体V598M单通道压力敏感性增强相关的散发性遗传性口形红细胞增多症中红细胞KCNN4活性增加。
Hemasphere. 2018 Oct;2(5):e55. doi: 10.1097/HS9.0000000000000055. Epub 2018 Oct 2.
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A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp.通过高通量膜片钳技术在红细胞中功能验证了一种新的Piezo1功能获得性突变。
Haematologica. 2019 May;104(5):e179-e183. doi: 10.3324/haematol.2018.201160. Epub 2018 Sep 20.
7
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.非洲人群中常见的 PIEZO1 等位基因导致 RBC 脱水并减弱疟原虫感染。
Cell. 2018 Apr 5;173(2):443-455.e12. doi: 10.1016/j.cell.2018.02.047. Epub 2018 Mar 22.
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Piezos thrive under pressure: mechanically activated ion channels in health and disease.压敏通道：健康与疾病中的机械激活型离子通道。
Nat Rev Mol Cell Biol. 2017 Dec;18(12):771-783. doi: 10.1038/nrm.2017.92. Epub 2017 Oct 4.
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Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.Piezo1通道感知全身身体活动，以重置心血管稳态并提高运动表现。
Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.
10
Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis.遗传性口形细胞增多症中PIEZO1功能障碍的新机制。
Blood. 2017 Oct 19;130(16):1845-1856. doi: 10.1182/blood-2017-05-786004. Epub 2017 Jul 17.
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