Clinical Oncology Department, Sohag University Hospital, Egypt.
Orthopaedics Department, Sohag University Hospital, Egypt.
Am J Otolaryngol. 2020 Jul-Aug;41(4):102486. doi: 10.1016/j.amjoto.2020.102486. Epub 2020 Apr 10.
Chondroblastoma is a rare bone tumour that often affects children more than adults. The adult cranial affection is a unique presentation of the disease (less than 2%) that mandates specific management. Through this pooled-analysis, we aimed to examine this disease group and obtain reliable scientific conclusions.
The literature was searched for case-reports of cranial chondroblastoma. Afterwards, a pooled analysis was done for the selected articles. The data in question were the patient's age, gender, disease site, modalities of treatment, disease control, salvage treatment, and disease-specific survival.
122 case reports were retrieved from the literature. The median age at diagnosis was 38.5 years. Up to the moment, the standard of care remains complete resection. The relapse-free survival was 29.5 months, with a three-year relapse rate of 9% and disease-specific mortality of 0%. Most of the relapses were salvaged excellently with excision. The strongest predictor for relapse was the post-resection residual disease, with three-years relapse rates of 23.8% and 2.4% for positive and negative residuals, respectively. Adjuvant Radiotherapy failed to improve the relapse rates.
Complete surgical excision is the standard of care. Post-surgical residual is the only adverse prognostic factor that predicts poor disease control.
成软骨细胞瘤是一种罕见的骨肿瘤，多见于儿童，成人颅部发病较为少见（<2%），需要特殊的治疗管理。通过本次汇总分析，我们旨在研究这一疾病类型，并获得可靠的科学结论。
我们对颅部成软骨细胞瘤的病例报告进行了文献检索。随后，对选定的文章进行了汇总分析。所关注的数据包括患者年龄、性别、疾病部位、治疗方式、疾病控制情况、挽救治疗和疾病特异性生存率。
我们从文献中检索到 122 例病例报告。诊断时的中位年龄为 38.5 岁。目前，标准治疗方法仍然是完全切除。无复发生存率为 29.5 个月，3 年复发率为 9%，疾病特异性死亡率为 0%。大多数复发患者通过切除获得了极好的挽救治疗效果。复发的最强预测因素是术后残留疾病，残留阳性和阴性的 3 年复发率分别为 23.8%和 2.4%。辅助放疗未能降低复发率。
完全手术切除是标准的治疗方法。术后残留是唯一预测疾病控制不良的不良预后因素。
