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戊聚糖多硫酸钠致视网膜毒性 1 例

Retinal Toxicity in a Patient on Pentosan Polysulfate Sodium.

机构信息

University of Wisconsin-Madison, Department of Ophthalmology, Madison, WI.

University of Wisconsin-Madison, Department of Ophthalmology, Madison, WI.

出版信息

Urology. 2020 Jul;141:e41-e42. doi: 10.1016/j.urology.2020.04.006. Epub 2020 Apr 17.

DOI:10.1016/j.urology.2020.04.006
PMID:32305545
Abstract

Pentosan Polysulfate Sodium (PPS) is commonly used in the treatment of interstitial cystitis/bladder pain syndrome. Recently there have been reported cases of retinal toxicity associated with long-term PPS use. We present a case of a 42-year-old female taking PPS for the last 10 years who was found to have signs of retinal toxicity, but was completely asymptomatic. PPS was discontinued after these retinal findings were discovered.

摘要

戊聚糖多硫酸钠(PPS)常用于治疗间质性膀胱炎/膀胱疼痛综合征。最近有报道称,长期使用 PPS 与视网膜毒性有关。我们报告了一例 42 岁女性,她在过去 10 年中一直服用 PPS,发现有视网膜毒性的迹象,但完全没有症状。发现这些视网膜病变后,停止使用 PPS。

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Retinal Toxicity in a Patient on Pentosan Polysulfate Sodium.戊聚糖多硫酸钠致视网膜毒性 1 例
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引用本文的文献

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Incidence and Risk of Retinopathy in Patients With and Without Interstitial Cystitis and Pentosan Polysulfate Sodium Use.患有和未患有间质性膀胱炎以及使用聚磺苯乙烯钠的患者中视网膜病变的发病率和风险。
J Vitreoretin Dis. 2023 Aug 7;7(5):412-419. doi: 10.1177/24741264231190978. eCollection 2023 Sep-Oct.
2
Pentosan associated retinal pigmentary changes: FDA's perspective on an emerging postmarketing safety finding.戊聚糖相关的视网膜色素变化:FDA 对一个新兴上市后安全性发现的看法。
Int Urogynecol J. 2021 Nov;32(11):2891-2897. doi: 10.1007/s00192-021-04970-0. Epub 2021 Sep 10.