Emory University School of Medicine, Atlanta, Georgia.
Department of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, Georgia ; and.
Retina. 2021 Jul 1;41(7):1562-1569. doi: 10.1097/IAE.0000000000003078.
To investigate patient-reported visual function among individuals taking pentosan polysulfate (PPS) for interstitial cystitis.
A 27-item online survey was distributed to an international mailing list of individuals with interstitial cystitis in November 2018. Demographic characteristics, PPS exposure history, subjective visual function, and previous macular diagnoses were queried. The impact of PPS use, grouped by tertile of cumulative exposure, on visual function and macular diagnoses was assessed with multivariate logistic regression.
The survey was completed by 912 respondents. Eight hundred and sixty-one (96.4%) were women, and the median age was 55 [interquartile range (IQR), 45-64 years]. Among PPS users, the median exposure was 547.5 g (IQR, 219-1,314 g). Respondents in the highest PPS exposure tertile were more likely to report difficulty with reading small print [adjusted odds ratio 2.29, 95% confidence interval (CI) 1.15-4.57] and to have a diagnosis of macular degeneration and/or pigmentary maculopathy (adjusted odds ratio 2.41, 95% CI 1.44-4.03) than unexposed respondents.
In this large sample of individuals with interstitial cystitis, those in the highest PPS exposure category were more likely to have difficulties reading small print and to report a previous diagnosis of macular disease. Further study of objective measures of visual function in PPS users is warranted.
调查接受聚戊烯多糖硫酸酯（PPS）治疗间质性膀胱炎患者的患者报告视觉功能。
2018 年 11 月，通过国际间质性膀胱炎邮寄名单分发了一份 27 项在线调查。询问了人口统计学特征、PPS 暴露史、主观视觉功能和以前的黄斑诊断。使用多元逻辑回归评估 PPS 使用（按累积暴露的三分位数分组）对视觉功能和黄斑诊断的影响。
共有 912 名受访者完成了调查。861 名（96.4%）为女性，中位年龄为 55 岁[四分位间距（IQR），45-64 岁]。在 PPS 用户中，中位暴露量为 547.5 克（IQR，219-1314 克）。暴露于 PPS 的最高三分位组的受访者更有可能报告阅读小字体有困难[调整后的优势比 2.29，95%置信区间（CI）1.15-4.57]，并且更有可能被诊断为黄斑变性和/或色素性视网膜炎（调整后的优势比 2.41，95%置信区间 1.44-4.03）比未暴露的受访者。
在这项大型间质性膀胱炎患者样本中，暴露于 PPS 的最高三分位数组的人更有可能阅读小字体有困难，并且更有可能报告以前患有黄斑疾病。需要进一步研究 PPS 使用者的客观视觉功能指标。
