Brooks M B, Matus R E, Leifer C E, Alfieri A A, Patnaik A K
Donaldson-Atwood Cancer Clinic, Animal Medical Center, New York, NY 10021.
J Vet Intern Med. 1988 Oct-Dec;2(4):206-11. doi: 10.1111/j.1939-1676.1988.tb00318.x.
The effect of adjuvant chemotherapy and combined chemotherapy and radiotherapy in 22 dogs with advanced canine tonsillar carcinoma (World Health Organization [WHO], T2-3 primary tumor with infiltration into surrounding tissues) was evaluated. There were four treatment groups of at least five dogs each. Combinations of chemotherapeutic drugs reported to have activity against squamous cell carcinoma in humans and dogs (doxorubicin, cisplatin, vinblastine, and cyclophosphamide) were administered after tonsillectomy. Radiation therapy (orthovoltage type, external beam) was combined with chemotherapy in one treatment group. The dogs that had combination radiation therapy and chemotherapy had higher response rates and significantly longer survival times. However, most dogs died of progression of disease.
评估了辅助化疗以及联合化疗和放疗对22只患有晚期犬扁桃体癌（世界卫生组织[WHO]，T2 - 3原发性肿瘤并浸润周围组织）的犬的疗效。共有四个治疗组，每组至少五只犬。在扁桃体切除术后给予据报道对人和犬的鳞状细胞癌有活性的化疗药物组合（阿霉素、顺铂、长春碱和环磷酰胺）。在一个治疗组中，放射治疗（深部X线型，外照射）与化疗联合使用。接受联合放疗和化疗的犬有更高的缓解率和显著更长的生存时间。然而，大多数犬死于疾病进展。
