Analytical chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Pharmaceutical Chemistry Department, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.
Analytical chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Chemistry Department, Faculty of Pharmacy, October 6 University, 6 October City, Giza, Egypt.
J Pharm Biomed Anal. 2020 Jul 15;186:113272. doi: 10.1016/j.jpba.2020.113272. Epub 2020 Apr 3.
Multiplex ion analyzers have been introduced recently for the assay of several inorganic ions, whilst electrochemists have extensively employed screen printed sensors for pharmaceutical analyses. This work aims to develop a USB pluggable sensor with a user-friendly design for multiplex analysis of oppositely charged co-formulated organic ions. The miniaturized screen-printed electrode was developed using silver ink on paper substrate. A compact sensor design was attained by including three electrodes, a single reference electrode along with an indicator electrode for each of the determined ions. Optimized PVC membranes were drop-casted over each of the indicator electrodes for the determination of phenylephrine HCl (PHE) and ibuprofen (IBU). The proposed multiplex potentiometric sensors exhibit Nernstian slopes of 59.2 ± 0.26 and -56.8 ± 0.16 mV/decade for PHE and IBU, respectively, with respective detection limits of 1.6 × 10 and 6.53 × 10 mol L. The fast and stable response of the developed sensor enabled the real-time monitoring of the combined dosage form dissolution. The dissolution profiles obtained by this potentiometric analyzer and an off-line separation technique were compared favourably, albeit our proposed in-line sensor reduced waste and time of analysis. The developed method successfully complies with the most demanding stipulations of green analytical chemistry.
最近，已经引入了用于测定几种无机离子的多重离子分析仪，而电化学工作者则广泛使用丝网印刷传感器进行药物分析。本工作旨在开发一种具有用户友好设计的 USB 即插即用传感器，用于对相反电荷的共配方有机离子进行多重分析。使用银油墨在纸质基底上开发了微型丝网印刷电极。通过包括三个电极、一个单个参比电极和每个测定离子的一个指示电极，实现了紧凑的传感器设计。为了测定盐酸苯肾上腺素（PHE）和布洛芬（IBU），在每个指示电极上滴铸了优化的 PVC 膜。所提出的多重电位传感器对 PHE 和 IBU 的斜率分别为 59.2±0.26 和 -56.8±0.16 mV/decade，相应的检测限分别为 1.6×10 和 6.53×10 mol L。开发的传感器具有快速稳定的响应，能够实时监测组合剂型的溶解情况。该电位分析仪和离线分离技术获得的溶解曲线进行了有利的比较，尽管我们提出的在线传感器减少了分析的浪费和时间。所开发的方法成功符合绿色分析化学最苛刻的规定。
