Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK; Centre for Medical Image Computing, University College London, London, UK.
Neurobiol Aging. 2020 Jul;91:5-14. doi: 10.1016/j.neurobiolaging.2020.03.008. Epub 2020 Mar 17.
This study investigated the relationship between white matter hyperintensities (WMH) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 controls, 107 individuals with a significant memory concern, 320 individuals with early mild cognitive impairment, 171 individuals with late mild cognitive impairment, and 151 individuals with AD, with 3T MRI and CSF Aβ1-42, total tau (t-tau), and phosphorylated tau (p-tau) data. Multiple linear regression models assessed the relationship between WMH and CSF Aβ1-42, t-tau, and p-tau. Directionally, a higher WMH burden was associated with lower CSF Aβ1-42 within each diagnostic group, with no evidence for a difference in the slope of the association across diagnostic groups (p = 0.4). Pooling all participants, this association was statistically significant after adjustment for t-tau, p-tau, age, diagnostic group, and APOE-ε4 status (p < 0.001). Age was the strongest predictor of WMH (partial R16%) compared with CSF Aβ1-42 (partial R5%). There was no evidence for an association with WMH and either t-tau or p-tau. These data are supportive of a link between amyloid burden and presumed vascular pathology.
本研究调查了脑白质高信号（WMH）与脑脊液（CSF）阿尔茨海默病（AD）生物标志物之间的关系。受试者包括 180 名对照者、107 名有明显记忆问题者、320 名早期轻度认知障碍者、171 名晚期轻度认知障碍者和 151 名 AD 患者，所有患者均接受了 3T MRI 和 CSF Aβ1-42、总 tau（t-tau）和磷酸化 tau（p-tau）检测。多元线性回归模型评估了 WMH 与 CSF Aβ1-42、t-tau 和 p-tau 之间的关系。在每个诊断组内，WMH 负担越高，CSF Aβ1-42 越低，且 across 诊断组的关联斜率没有差异（p = 0.4）。在调整了 t-tau、p-tau、年龄、诊断组和 APOE-ε4 状态后，pooling 所有参与者，这种关联具有统计学意义（p < 0.001）。与 CSF Aβ1-42（partial R5%）相比，年龄是 WMH 的最强预测因子（partial R16%）。WMH 与 t-tau 或 p-tau 之间没有关联的证据。这些数据支持淀粉样蛋白负荷与假定的血管病理学之间存在联系。
