脑脊液淀粉样蛋白是从衰老到阿尔茨海默病的整个疾病过程中脑白质高信号的一致预测因子。
CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease.
机构信息
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK; Centre for Medical Image Computing, University College London, London, UK.
出版信息
Neurobiol Aging. 2020 Jul;91:5-14. doi: 10.1016/j.neurobiolaging.2020.03.008. Epub 2020 Mar 17.
This study investigated the relationship between white matter hyperintensities (WMH) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 controls, 107 individuals with a significant memory concern, 320 individuals with early mild cognitive impairment, 171 individuals with late mild cognitive impairment, and 151 individuals with AD, with 3T MRI and CSF Aβ1-42, total tau (t-tau), and phosphorylated tau (p-tau) data. Multiple linear regression models assessed the relationship between WMH and CSF Aβ1-42, t-tau, and p-tau. Directionally, a higher WMH burden was associated with lower CSF Aβ1-42 within each diagnostic group, with no evidence for a difference in the slope of the association across diagnostic groups (p = 0.4). Pooling all participants, this association was statistically significant after adjustment for t-tau, p-tau, age, diagnostic group, and APOE-ε4 status (p < 0.001). Age was the strongest predictor of WMH (partial R16%) compared with CSF Aβ1-42 (partial R5%). There was no evidence for an association with WMH and either t-tau or p-tau. These data are supportive of a link between amyloid burden and presumed vascular pathology.
本研究调查了脑白质高信号（WMH）与脑脊液（CSF）阿尔茨海默病（AD）生物标志物之间的关系。受试者包括 180 名对照者、107 名有明显记忆问题者、320 名早期轻度认知障碍者、171 名晚期轻度认知障碍者和 151 名 AD 患者，所有患者均接受了 3T MRI 和 CSF Aβ1-42、总 tau（t-tau）和磷酸化 tau（p-tau）检测。多元线性回归模型评估了 WMH 与 CSF Aβ1-42、t-tau 和 p-tau 之间的关系。在每个诊断组内，WMH 负担越高，CSF Aβ1-42 越低，且 across 诊断组的关联斜率没有差异（p = 0.4）。在调整了 t-tau、p-tau、年龄、诊断组和 APOE-ε4 状态后，pooling 所有参与者，这种关联具有统计学意义（p < 0.001）。与 CSF Aβ1-42（partial R5%）相比，年龄是 WMH 的最强预测因子（partial R16%）。WMH 与 t-tau 或 p-tau 之间没有关联的证据。这些数据支持淀粉样蛋白负荷与假定的血管病理学之间存在联系。
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