Butler Hospital Memory & Aging Program, Providence, Rhode Island, USA.
Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
Alzheimers Dement. 2024 Oct;20(10):7220-7231. doi: 10.1002/alz.14207. Epub 2024 Sep 1.
The relationship between cerebrovascular disease (CVD) and amyloid beta (Aβ) in Alzheimer's disease (AD) is understudied. We hypothesized that magnetic resonance imaging (MRI)-based CVD biomarkers-including cerebral microbleeds (CMBs), lacunar infarction, and white matter hyperintensities (WMHs)-would correlate with Aβ positivity on positron emission tomography (Aβ-PET).
We cross-sectionally analyzed data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1352). Logistic regression was used to calculate odds ratios (ORs), with Aβ-PET positivity as the standard-of-truth.
Following adjustment, WMHs (OR = 1.25) and superficial CMBs (OR = 1.45) remained positively associated with Aβ-PET positivity (p < 0.001). Deep CMBs and lacunes exhibited a varied relationship with Aβ-PET in cognitive subgroups. The combined diagnostic model, which included CVD biomarkers and other accessible measures, significantly predicted Aβ-PET (pseudo-R= 0.41).
The study highlights the translational value of CVD biomarkers in diagnosing AD, and underscores the need for more research on their inclusion in diagnostic criteria.
gov: ADNI-2 (NCT01231971), ADNI-3 (NCT02854033).
Cerebrovascular biomarkers linked to amyloid beta (Aβ) in Alzheimer's disease (AD). White matter hyperintensities and cerebral microbleeds reliably predict Aβ-PET positivity. Relationships with Aβ-PET vary by cognitive stage. Novel accessible model predicts Aβ-PET status. Study supports multimodal diagnostic approaches.
脑血管疾病 (CVD) 与阿尔茨海默病 (AD) 中淀粉样蛋白β (Aβ) 的关系尚未得到充分研究。我们假设磁共振成像 (MRI) 为基础的 CVD 生物标志物——包括脑微出血 (CMBs)、腔隙性梗死和脑白质高信号 (WMHs)——与正电子发射断层扫描 (Aβ-PET) 上的 Aβ 阳性相关。
我们对阿尔茨海默病神经影像学倡议 (ADNI) 的数据进行了横断面分析 (N=1352)。采用逻辑回归计算比值比 (OR)，以 Aβ-PET 阳性为标准。
在调整后，WMHs（OR=1.25）和浅表 CMBs（OR=1.45）仍与 Aβ-PET 阳性呈正相关（p<0.001）。深部 CMBs 和腔隙与认知亚组的 Aβ-PET 存在不同的关系。包括 CVD 生物标志物和其他可获得的测量指标的联合诊断模型，显著预测了 Aβ-PET（伪 R=0.41）。
该研究强调了 CVD 生物标志物在诊断 AD 中的转化价值，并强调了需要更多的研究来纳入其在诊断标准中的应用。
gov: ADNI-2（NCT01231971），ADNI-3（NCT02854033）。
脑血管生物标志物与阿尔茨海默病 (AD) 中的淀粉样蛋白β (Aβ) 相关。白质高信号和脑微出血可靠地预测 Aβ-PET 阳性。与 Aβ-PET 的关系因认知阶段而异。新型可及模型预测 Aβ-PET 状态。研究支持多模态诊断方法。
