Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
School of Biology, University of St. Andrews, St. Andrews, UK.
J Neurochem. 2020 Nov;155(3):231-249. doi: 10.1111/jnc.15027. Epub 2020 May 23.
17β-hydroxysteroid dehydrogenase (17β-HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important functions in the metabolism, development and aging of the neural system, where it is involved in the homeostasis of neurosteroids, especially in regard to estradiol, changes in which make it an essential part of neurodegenerative pathology. These roles therefore, indicate that 17β-HSD10 may be a possible druggable target for neurodegenerative diseases including Alzheimer's disease (AD), and in hormone-dependent cancer. The objective of this review was to provide a summary about physiological functions and pathological roles of 17β-HSD10 and the modulators of its activity.
17β-羟甾脱氢酶 (17β-HSD10) 是一种多功能的人类酶，作为一种结构成分和许多代谢途径的催化剂都具有重要作用。这种线粒体酶在神经系统的代谢、发育和衰老中具有重要功能，在神经甾体的动态平衡中发挥作用，特别是在雌二醇方面，其变化使其成为神经退行性病理学的重要组成部分。因此，这些作用表明 17β-HSD10 可能是包括阿尔茨海默病 (AD) 和激素依赖性癌症在内的神经退行性疾病的潜在治疗靶点。本综述的目的是提供关于 17β-HSD10 的生理功能和病理作用及其活性调节剂的概述。
