Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People's Republic of China.
Int J Food Sci Nutr. 2020 Dec;71(8):965-978. doi: 10.1080/09637486.2020.1754351. Epub 2020 Apr 19.
High-fat diet (HFD)-feeding induces changes in the microbiome and increases intestinal permeability by impairing tight junction (TJ) protein function, which may explain the insulin resistance (IR) and associated pathologies. We aimed to determine the effects of resveratrol (RES) on the gut microbiome and intestinal TJ proteins. Results showed that RES administration improved the lipid profile, and ameliorated the endotoxemia, inflammation, intestinal barrier defect and glucose intolerance in the HFD-fed mice. Furthermore, it modified the gut microbial composition, reducing the proportion of Firmicutes and the Firmicutes-toBacteroidetes ratio. Moreover, Verrucomicrobia and were much more abundant in the HFD + RES group. RES also significantly reduced the abundance of and . These findings suggest that RES may be useful for the treatment of IR and associated metabolic diseases.
高脂肪饮食（HFD）喂养通过损害紧密连接（TJ）蛋白功能引起微生物组的变化，并增加肠道通透性，这可能解释了胰岛素抵抗（IR）和相关的病理。我们旨在确定白藜芦醇（RES）对肠道微生物组和肠道 TJ 蛋白的影响。结果表明，RES 给药改善了 HFD 喂养小鼠的脂质谱，并改善了内毒素血症、炎症、肠道屏障缺陷和葡萄糖不耐受。此外，它改变了肠道微生物组成，降低了厚壁菌门的比例和厚壁菌门与拟杆菌门的比例。此外，拟杆菌属和阿克曼氏菌属在 HFD+RES 组中更为丰富。RES 还显著降低了和 的丰度。这些发现表明，RES 可能对治疗 IR 和相关代谢疾病有用。
