Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, NY, USA.
Division of Transfusion Medicine Service Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY, USA.
Eur J Paediatr Neurol. 2020 Jul;27:94-97. doi: 10.1016/j.ejpn.2020.04.001. Epub 2020 Apr 10.
There is limited data available on the safety of therapeutic plasma exchange (TPE) for paediatric neuro-immunological disorders (PNID). In this study, we report our data on safety and feasibility of TPE for these disorders.
Retrospective chart review was performed to include all patient who received TPE for four major PNID conditions: autoimmune encephalitis (AIE), acute disseminated encephalomyelitis (ADEM), Neuromyelitis optic spectrum disorder (NMOSD) and transverse myelitis (TM). We recorded minor and major adverse effects (AEs) associated with each TPE procedure. Secondary analysis also looked at the efficacy data of TPE on these patients.
Thirty-two patients with PNID received a total of 186 TPE cycles. Out of these, only 1 cycle (0.89%) in AIE subgroup, 1 (4.3%) in NMOSD and 1 (4.5%) in TM had adverse effects. No patients had major side effects.
TPE was safe and well tolerated in our PNID patients.
关于治疗性血浆置换（TPE）治疗儿科神经免疫性疾病（PNID）的安全性数据有限。在这项研究中，我们报告了 TPE 治疗这些疾病的安全性和可行性数据。
回顾性病历审查纳入了所有接受 TPE 治疗的四种主要 PNID 疾病的患者：自身免疫性脑炎（AIE）、急性播散性脑脊髓炎（ADEM）、视神经脊髓炎谱系障碍（NMOSD）和横贯性脊髓炎（TM）。我们记录了与每个 TPE 程序相关的轻微和严重不良事件（AE）。二次分析还观察了 TPE 对这些患者的疗效数据。
32 名 PNID 患者共接受了 186 个 TPE 周期。其中，AIE 亚组仅有 1 个周期（0.89%）、NMOSD 有 1 个（4.3%）和 TM 有 1 个（4.5%）出现不良反应。没有患者出现严重副作用。
TPE 在我们的 PNID 患者中是安全且耐受良好的。
